سعر لاميفين 125 مجم 14 قرص 2024

Lamifen 125mg 14 tab: terbinafine 125 mg oral tablets, pack of 14, by EGPI (Egypt market); allylamine antifungal.

• Very common: decreased appetite, gastrointestinal symptoms (fullness, dyspepsia, nausea, abdominal pain, diarrhoea), rash, urticaria, arthralgia and myalgia. Common: headache. Uncommon: taste disturbance including loss of taste (usually recovers within weeks after stopping). Rare: serious hepatic dysfunction.General active-ingredient information · electronic medicines compendium (emc), UK

• Known hypersensitivity to terbinafine or to any excipient.General active-ingredient information · electronic medicines compendium (emc), UK
• Chronic or active hepatic disease.General active-ingredient information · electronic medicines compendium (emc), UK

• Hepatotoxicity, including very rare serious liver failure (some fatal or requiring transplant), may occur with or without pre-existing liver disease; perform liver function tests before treatment and periodically (after 4-6 weeks), and stop immediately if they rise or if symptoms of liver dysfunction appear (pruritus, persistent nausea, anorexia, jaundice, vomiting, fatigue, right upper abdominal pain, dark urine, pale stools).General active-ingredient information · electronic medicines compendium (emc), UK
• Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS) have been very rarely reported; stop treatment if a progressive skin rash occurs. Use with caution in psoriasis (rare exacerbation).General active-ingredient information · electronic medicines compendium (emc), UK
• Very rare blood dyscrasias (neutropenia, agranulocytosis, thrombocytopenia, pancytopenia) have been reported; evaluate and consider stopping treatment.General active-ingredient information · electronic medicines compendium (emc), UK

• RifampicinRifampicin increased terbinafine clearance by 100%.electronic medicines compendium (emc), UK
• Fluconazole and other dual CYP2C9/CYP3A4 inhibitors (e.g. ketoconazole, amiodarone)Fluconazole increased terbinafine Cmax and AUC by 52% and 69%; similar increases may occur with other dual CYP2C9/CYP3A4 inhibitors.electronic medicines compendium (emc), UK
• Drugs metabolised mainly by CYP2D6 (e.g. tricyclic antidepressants, beta-blockers, SSRIs, class 1A/1B/1C antiarrhythmics, MAO-B inhibitors)Terbinafine inhibits CYP2D6-mediated metabolism; may be clinically relevant especially for drugs with a narrow therapeutic window.electronic medicines compendium (emc), UK
• CimetidineCimetidine decreased terbinafine clearance by 30%.electronic medicines compendium (emc), UK

• Liver function tests before starting and periodically (after 4-6 weeks of treatment); evaluate any blood dyscrasia.General active-ingredient information · electronic medicines compendium (emc), UK

• Terbinafine: Allylamine antifungal that inhibits fungal squalene epoxidase, causing ergosterol deficiency and intracellular squalene accumulation and resulting in fungal cell death; fungicidal against dermatophytes (UK Lamisil SmPC 5.1).