سعر ليفليومين 20 مجم 10 أقراص 2022

Leflunomide 20 mg tablets, pack of 10 (1 strip).

• Treatment of adults with active rheumatoid arthritis.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: diarrhoea, elevated liver enzymes (ALT and AST), alopecia and rash.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Pregnancy; severe hepatic impairment; hypersensitivity to leflunomide or excipients; current teriflunomide treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: embryo-fetal toxicity (exclude pregnancy before starting, use effective contraception, stop and start accelerated elimination if pregnancy occurs) and hepatotoxicity including fatal liver failure.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Immunosuppression and bone marrow suppression with serious infections (screen for tuberculosis), Stevens-Johnson syndrome/TEN/DRESS, peripheral neuropathy, interstitial lung disease, hypertension; avoid live vaccines.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• TeriflunomideCo-administration is contraindicated.DailyMed (U.S. National Library of Medicine)
• Methotrexate and other hepatotoxic or immunosuppressive drugsIncreased risk of hepatotoxicity/myelosuppression; start without a loading dose and monitor closely.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnancy (teratogenicity and embryo-lethality in animals); if pregnancy occurs, stop treatment and begin accelerated elimination.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Advise discontinuation of breastfeeding during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Leflunomide: Isoxazole immunomodulator; its active metabolite teriflunomide inhibits dihydroorotate dehydrogenase (de novo pyrimidine synthesis) and has antiproliferative activity.