سعر رافيكس 10مجم 10 اقراص 2022

Leflunomide 10 mg tablets, pack of 10 (Sigma, Egypt); pyrimidine synthesis inhibitor DMARD.

• Treatment of adults with active rheumatoid arthritis.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions in RA: diarrhoea, elevated liver enzymes (ALT and AST), alopecia and rash.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregnancy (may cause fetal harm).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to leflunomide or any component (anaphylaxis reported).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: embryo-fetal toxicity - exclude pregnancy before starting, use effective contraception, and use the accelerated elimination procedure after stopping.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: hepatotoxicity - severe, including fatal, liver injury; do not use with pre-existing liver disease or ALT >2x ULN; monitor ALT monthly for 6 months then every 6-8 weeks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Immunosuppression, bone marrow suppression and serious infections (including TB); screen for TB before starting; live vaccines not recommended.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• WarfarinTeriflunomide may decrease peak INR by about 25%; monitor INR closely.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnancy because of potential fetal harm; teratogenicity and embryo-lethality occurred in animal studies at exposures below human levels.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No lactation studies; advise discontinuing breastfeeding during treatment because of potential serious adverse reactions in the infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)