سعر ليبسيرامب 4مجم 14 قرص 2026

Perampanel 4 mg film-coated tablets, a non-competitive AMPA glutamate receptor antagonist antiepileptic.

• Partial-onset seizures with or without secondarily generalized seizures in patients with epilepsy 4 years of age and older (monotherapy or adjunctive therapy).Population: Patients 4 years and olderDailyMed (U.S. National Library of Medicine)
• Adjunctive therapy for primary generalized tonic-clonic seizures in patients with epilepsy 12 years of age and older.Population: Patients 12 years and olderDailyMed (U.S. National Library of Medicine)
• Treatment of seizures in adults and children over 12 years (directory indication text).

• Most common adverse reactions include dizziness, somnolence, fatigue, irritability, falls, nausea, weight gain, vertigo, ataxia, headache, vomiting, contusion, abdominal pain and anxiety.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• None listed in the US label.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: serious or life-threatening psychiatric and behavioral reactions (aggression, hostility, irritability, anger, homicidal ideation and threats). Monitor during treatment and for at least 1 month after the last dose; reduce the dose if symptoms occur and stop permanently for persistent severe or worsening symptoms.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Suicidal behavior and ideation (antiepileptic class warning).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Dizziness, gait disturbance, somnolence and fatigue; patients should not drive or operate machinery until they know how they are affected. Falls have occurred.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Levonorgestrel-containing hormonal contraceptivesPerampanel 12 mg per day reduced levonorgestrel exposure by about 40% and may make levonorgestrel-containing contraceptives less effective; additional non-hormonal contraception is recommended.DailyMed (U.S. National Library of Medicine)
• Moderate or strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, oxcarbazepine)Markedly lower perampanel plasma levels (by about 50-67%); a higher starting dose (4 mg) is recommended and patients should be monitored when these drugs are added or stopped.DailyMed (U.S. National Library of Medicine)
• Alcohol and other CNS depressantsMay increase CNS depression; effects on complex tasks such as driving were additive or supra-additive to the impairment caused by alcohol.DailyMed (U.S. National Library of Medicine)

• There are no adequate data on developmental risk in pregnant women; perampanel caused developmental toxicity in pregnant rats and rabbits at clinically relevant doses. A pregnancy registry (NAAED) exists.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk or effects on the breastfed infant; perampanel and/or its metabolites are present in rat milk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Perampanel: Non-competitive antagonist of the ionotropic AMPA glutamate receptor on post-synaptic neurons; the precise antiepileptic mechanism in humans is unknown (US FYCOMPA label).