سعر ليبيزاد 20 مجم 30 قرص 2022

Lipizad 20 mg (Grand Pharma / Zad, Egypt): pravastatin 20 mg tablets, an HMG-CoA reductase inhibitor (statin); pack of 30.

• Primary hypercholesterolaemia or mixed dyslipidaemia as adjunct to diet; primary and secondary cardiovascular prevention; reduction of post-transplantation hyperlipidaemia in patients on immunosuppressive therapy after solid organ transplantation.Population: Adults; children and adolescents 8-18 years with HeFHelectronic medicines compendium (eMC)
• Reduce risk of MI, revascularisation and CV mortality in adults with elevated LDL-C without clinically evident CHD, and of coronary death, MI, revascularisation, stroke/TIA in adults with clinically evident CHD; adjunct to diet to reduce LDL-C in primary hyperlipidaemia and in HeFH aged 8 years and older; primary dysbetalipoproteinaemia and hypertriglyceridaemia in adults.Population: Adults; pediatric patients 8 years and older with HeFHDailyMed (U.S. National Library of Medicine)

• In placebo-controlled trials (40 mg), uncommon: dizziness, headache, sleep disturbance, insomnia, vision disturbance, dyspepsia/heartburn, abdominal pain, nausea/vomiting, constipation, diarrhoea, flatulence, pruritus, rash, urticaria, scalp/hair abnormality, abnormal urination, sexual dysfunction, fatigue; skeletal-muscle effects and transaminase elevations also reported.International label, same formulation · electronic medicines compendium (eMC)

• Hypersensitivity; active liver disease including unexplained persistent serum transaminase elevation exceeding 3 x ULN; pregnancy and lactation.International label, same formulation · electronic medicines compendium (eMC)
• Acute liver failure or decompensated cirrhosis; hypersensitivity to pravastatin or any excipient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myalgia, myopathy and very rarely rhabdomyolysis; measure CK with unexplained muscle symptoms and interrupt if CK > 5 x ULN or severe symptoms; predisposing factors include age > 65, uncontrolled hypothyroidism and renal impairment; combination with fibrates not recommended; must not be co-administered with systemic fusidic acid or within 7 days of stopping it; monitor transaminases and discontinue if ALT/AST exceed 3 x ULN persistently.International label, same formulation · electronic medicines compendium (eMC)

• CiclosporinUK: start pravastatin at 20 mg once daily and titrate to 40 mg with caution.electronic medicines compendium (eMC)
• CiclosporinUS: recommended starting dosage 10 mg once daily; maximum 20 mg once daily.DailyMed (U.S. National Library of Medicine)
• Systemic fusidic acidMust not be co-administered or used within 7 days of stopping fusidic acid (rhabdomyolysis reports).electronic medicines compendium (eMC)

• Contraindicated during pregnancy; give to women of childbearing potential only when unlikely to conceive and informed of the risk; discontinue if pregnancy is planned or occurs.International label, same formulation · electronic medicines compendium (eMC)
• Discontinue when pregnancy is recognised, or consider ongoing therapeutic needs; may cause fetal harm based on mechanism; observational data over decades have not identified a drug-associated risk of major congenital malformations.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• A small amount is excreted in human breast milk; contraindicated during breastfeeding.International label, same formulation · electronic medicines compendium (eMC)

• Pravastatin sodium: Hydrophilic competitive inhibitor of HMG-CoA reductase; reduces hepatic cholesterol synthesis and increases LDL-receptor activity.