سعر لودليس 5/20 مجم 30كبسولة 2024

Loadless 5/20mg 30 cap: fixed-dose capsules of amlodipine 5 mg (dihydropyridine calcium channel blocker) and benazepril 20 mg (ACE inhibitor) for hypertension.

• Treatment of hypertension in patients not adequately controlled on monotherapy with either amlodipine or benazepril.Population: AdultsDailyMed (US National Library of Medicine)

• Discontinuation due to adverse reactions occurred in 4% (vs 3% placebo); the most common reasons were cough and oedema.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• History of angioedema (with or without prior ACE-inhibitor treatment) or hypersensitivity to benazepril or amlodipine; co-administration with a neprilysin inhibitor (e.g. sacubitril) or within 36 hours of switching; co-administration with aliskiren in patients with diabetes.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting on the renin-angiotensin system can cause fetal injury and death; discontinue as soon as pregnancy is detected.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Angioedema of the face, lips, tongue, glottis or larynx can occur at any time and may be fatal; discontinue and treat immediately. Symptomatic hypotension may occur, especially in volume/salt-depleted patients or those with heart failure or aortic/mitral stenosis.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Changes in renal function including acute renal failure, hyperkalaemia, and rare cholestatic hepatitis/hepatic failure have been reported with RAS-acting drugs/ACE inhibitors.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Potassium supplements / potassium-sparing diureticsRisk of hyperkalaemia.DailyMed (US National Library of Medicine)
• LithiumIncreased serum lithium levels and lithium toxicity.DailyMed (US National Library of Medicine)
• NSAIDsRisk of renal dysfunction and loss of antihypertensive effect.DailyMed (US National Library of Medicine)

• Can cause fetal harm: use of RAS-acting drugs in the second and third trimesters reduces fetal renal function and increases fetal and neonatal morbidity and death (oligohydramnios, skull hypoplasia, anuria, hypotension, renal failure). Discontinue as soon as pregnancy is detected.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Minimal benazepril/benazeprilat passes into milk (<0.1% of maternal dose); amlodipine is present in milk (median relative infant dose 4.2%) with no observed infant effects.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.
• Benazepril: ACE inhibitor; reduces formation of angiotensin II.