سعر لوجي ماكس 30 قرص 2023

Logimax s.r. 30 tablets: felodipine + metoprolol sustained-release tablets (AstraZeneca); fixed combination for hypertension. Strength per tablet not stated by the Egyptian sources opened.

• Second-line treatment of arterial hypertension when monotherapy is not effectivePopulation: AdultsANSM (Agence nationale de sécurité du médicament et des produits de santé), France

• Generally mild and reversible: headache, ankle oedema, flushing, dizziness, nausea and fatigue, mostly related to felodipine vasodilation and dose-dependent at start of treatment. Felodipine: peripheral oedema very common; headache and flushing common. Castor oil may cause digestive upset.International label, equivalent formulation · ANSM (Agence nationale de sécurité du médicament et des produits de santé), France

• Hypersensitivity; history of anaphylaxis; severe asthma/COPD; pregnancy; acute myocardial infarction; unstable angina; 2nd/3rd-degree AV block; unstable decompensated heart failure; clinically relevant sinus bradycardia (<45-50 bpm); sick sinus syndrome; untreated phaeochromocytoma; cardiogenic shock; severe Raynaud phenomenon/peripheral arterial disease; haemodynamically significant valvular stenosis; dynamic outflow obstruction; hypotension; intestinal occlusion (contains castor oil).International label, equivalent formulation · ANSM (Agence nationale de sécurité du médicament et des produits de santé), France

• Never stop abruptly, especially in ischaemic heart disease (risk of serious arrhythmia, myocardial infarction or sudden death); reduce over 1-2 weeks.International label, equivalent formulation · ANSM (Agence nationale de sécurité du médicament et des produits de santé), France
• May cause hypotension and myocardial ischaemia in susceptible patients; generally not recommended with bepridil, diltiazem, verapamil or IV dantrolene, nor during breastfeeding; do not give IV verapamil-type calcium antagonists; avoid CYP3A4 inhibitors/inducers. Mild gingival hyperplasia reported with marked gingivitis.International label, equivalent formulation · ANSM (Agence nationale de sécurité du médicament et des produits de santé), France
• Dizziness or fatigue may affect ability to drive or use machines.International label, equivalent formulation · ANSM (Agence nationale de sécurité du médicament et des produits de santé), France

• Strong CYP3A4 inhibitors (clarithromycin, erythromycin, itraconazole, ketoconazole, ritonavir, voriconazole), cimetidine, grapefruit juiceIncrease felodipine levels (more hypotension/oedema); clinical monitoring and dose adjustment.ANSM (Agence nationale de sécurité du médicament et des produits de santé), France
• CYP3A4 inducers (carbamazepine, phenytoin, phenobarbital, rifampicin, St John's wort, efavirenz, nevirapine)Decrease felodipine plasma concentrations; monitor and adjust.ANSM (Agence nationale de sécurité du médicament et des produits de santé), France
• CYP2D6 inhibitors (quinidine, propafenone, paroxetine, fluoxetine, sertraline, celecoxib, terbinafine)May increase metoprolol plasma concentrations.ANSM (Agence nationale de sécurité du médicament et des produits de santé), France

• Must not be taken during pregnancy (contraindicated). Felodipine was teratogenic and fetotoxic in animals; neonates of mothers on beta-blockers may have bradycardia, respiratory distress or hypoglycaemia for several days.International label, equivalent formulation · ANSM (Agence nationale de sécurité du médicament et des produits de santé), France
• Felodipine and beta-blockers are excreted in milk (hypoglycaemia and bradycardia described with some beta-blockers); breastfeeding is not recommended during treatment.International label, equivalent formulation · ANSM (Agence nationale de sécurité du médicament et des produits de santé), France

• Felodipine: Vascular-selective calcium antagonist that reduces peripheral vascular resistance.
• Metoprolol: Beta-1-selective blocker that reduces heart rate and cardiac output; additive antihypertensive effect with felodipine.