سعر لوساشيزو 5 مجم 20 قرص 2026

Loschizo 5 mg by Mash Premiere (Egypt): asenapine sublingual tablets, an atypical antipsychotic for schizophrenia and bipolar I disorder.

• Schizophrenia.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Bipolar I disorder: acute monotherapy of manic or mixed episodes.Population: Adults and paediatric patients 10-17 yearsDailyMed (U.S. National Library of Medicine)
• Bipolar I disorder: adjunctive treatment to lithium or valproate for acute manic or mixed episodes, and maintenance monotherapy.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Adult short-term trials: frequent reactions include somnolence, insomnia, akathisia, extrapyramidal symptoms, dizziness, oral hypoaesthesia, constipation, vomiting and increased weight.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Severe hepatic impairment (Child-Pugh C); known hypersensitivity to asenapine or any component (reactions have included anaphylaxis, angioedema, hypotension, tachycardia, swollen tongue, dyspnoea, wheezing and rash).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death; not approved for dementia-related psychosis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Cerebrovascular adverse reactions in elderly dementia patients; neuroleptic malignant syndrome; tardive dyskinesia; metabolic changes (hyperglycaemia, dyslipidaemia, weight gain); hypersensitivity reactions; orthostatic hypotension and syncope; falls; leukopenia, neutropenia and agranulocytosis; QT prolongation; hyperprolactinaemia; seizures; somnolence with cognitive and motor impairment; body temperature dysregulation; dysphagia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Antihypertensive drugsAsenapine may enhance the effects of some antihypertensive agents (risk of hypotension).DailyMed (U.S. National Library of Medicine)
• Paroxetine (and other CYP2D6 substrates and inhibitors)Reduce the paroxetine dose by half when used in combination with asenapine.DailyMed (U.S. National Library of Medicine)
• Fluvoxamine (strong CYP1A2 inhibitor)Asenapine is metabolised by CYP1A2; a marginal exposure increase was seen with a suboptimal fluvoxamine dose and full therapeutic doses may cause a larger increase; use with caution.DailyMed (U.S. National Library of Medicine)

• No lactation studies in humans; asenapine is excreted in rat milk; weigh the benefits of breastfeeding against the mother's clinical need and possible effects on the infant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Asenapine: Mechanism unknown; efficacy is proposed to be mediated through a combination of dopamine D2 and serotonin 5-HT2A receptor antagonism.