سعر سيكوسابين 10 مجم 10 اقراص تحت اللسان 2026

Asenapine 10 mg sublingual tablets, pack of 10, marketed in Egypt (Debeiky/Advocure).

• Schizophrenia in adults.Population: AdultsDailyMed (NLM)
• Bipolar I disorder: acute monotherapy of manic or mixed episodes (adults and children 10-17 years), adjunct to lithium or valproate (adults), maintenance monotherapy (adults).Population: Adults; children 10-17 years (monotherapy of mania)DailyMed (NLM)

• Label lists the adverse reactions discussed in warnings (NMS, tardive dyskinesia, metabolic changes, hypersensitivity, orthostatic hypotension, falls, leukopenia, QT prolongation, hyperprolactinemia, seizures).International label, same formulation · DailyMed (NLM)

• Severe hepatic impairment (Child-Pugh C).International label, same formulation · DailyMed (NLM)
• History of hypersensitivity to asenapine (anaphylaxis, angioedema, hypotension, tachycardia, swollen tongue, dyspnea, wheezing, rash).International label, same formulation · DailyMed (NLM)

• Boxed warning: increased mortality in elderly patients with dementia-related psychosis; not approved for this use.International label, same formulation · DailyMed (NLM)
• Neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes (hyperglycemia, dyslipidemia, weight gain), orthostatic hypotension, leukopenia/neutropenia/agranulocytosis, QT prolongation, hyperprolactinemia and seizures.International label, same formulation · DailyMed (NLM)

• Antihypertensive drugsAsenapine may enhance hypotensive effects; monitor blood pressure.DailyMed (NLM)
• Paroxetine (CYP2D6 substrate and inhibitor)Reduce paroxetine dose by half when combined with asenapine.DailyMed (NLM)
• Strong CYP1A2 inhibitors (e.g. fluvoxamine)Asenapine is metabolised by CYP1A2; exposure may increase.DailyMed (NLM)

• No human data on drug-associated risk; a pregnancy exposure registry exists.International label, same formulation · DailyMed (NLM)
• No human lactation data; asenapine is excreted in rat milk.International label, same formulation · DailyMed (NLM)