سعر لوبيستون 24مكجم 20 كبسولة 2024

Lubistone 24 mcg 20 caps (Egypt; Medizen for Pharmaceutical Industries > Alwady Pharmaceutical Co. (ALPAC)): oral capsules containing lubiprostone 24 mcg, a locally acting chloride channel (ClC-2) activator used for chronic constipation.

• Chronic idiopathic constipation in adults (24 mcg twice daily).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Opioid-induced constipation in adults with chronic non-cancer pain (24 mcg twice daily); effectiveness with diphenylheptane opioids such as methadone not established.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Irritable bowel syndrome with constipation in women 18 years and older (8 mcg twice daily).Population: Women 18 years and olderDailyMed (U.S. National Library of Medicine)

• Most common (>4%): CIC - nausea (about 29%), diarrhea, headache, abdominal pain, abdominal distension and flatulence; OIC - nausea and diarrhea; IBS-C - nausea, diarrhea and abdominal pain. Postmarketing: syncope/hypotension, tachycardia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known or suspected mechanical gastrointestinal obstruction.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Nausea (food may reduce it); diarrhea (avoid in severe diarrhea; stop if severe diarrhea occurs); syncope and hypotension (mostly with 24 mcg twice daily, sometimes within an hour of a dose); dyspnea (chest tightness, onset within 30-60 minutes of the first dose, may recur); evaluate for bowel obstruction before starting if suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Diphenylheptane opioids (e.g. methadone)Shown in nonclinical studies to dose-dependently reduce ClC-2 activation by lubiprostone; possible dose-dependent loss of efficacy (no in vivo studies).DailyMed (U.S. National Library of Medicine)
• Medicines that lower blood pressureConcomitant use was reported in several postmarketing cases of syncope or hypotension and may increase that risk.DailyMed (U.S. National Library of Medicine)

• Limited human data are insufficient to inform drug-associated risk; animal studies showed no increase in structural malformations, but a dose-dependent increase in fetal loss occurred in guinea pigs (probably secondary to maternal toxicity); based on animal data may cause fetal harm.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; not found in milk of lactating rats; if present may cause diarrhea in the breastfed infant, so monitor infants for diarrhea.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Lubiprostone: Locally acting activator of ClC-2 chloride channels on the apical membrane of the intestinal epithelium; increases chloride-rich intestinal fluid secretion and intestinal motility without altering serum sodium or potassium (US label).