سعر لوبروستام 8ميكروجرام 20كبسول 2022

Luprostam 8 mcg capsules (20) by Kahira for Bioxell Pharma (Egypt): lubiprostone, a locally acting chloride channel activator used as a laxative.

• Chronic idiopathic constipation (CIC) in adults (24 mcg twice daily).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Opioid-induced constipation (OIC) in adults with chronic non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent opioid dosage escalation (24 mcg twice daily); effectiveness with diphenylheptane opioids such as methadone has not been established.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Irritable bowel syndrome with constipation (IBS-C) in women at least 18 years old (8 mcg twice daily).Population: Women aged 18 years and olderDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions: nausea, diarrhea, headache, abdominal pain, abdominal distension and flatulence.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known or suspected mechanical gastrointestinal obstruction.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nausea may occur; taking it with food may reduce nausea symptoms.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Diarrhea: avoid in patients with severe diarrhea; patients should discontinue and contact their provider if severe diarrhea occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Syncope and hypotension have been reported, usually within an hour of the first or subsequent doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Methadone and other diphenylheptane opioidsDiphenylheptane opioids (e.g. methadone) may reduce the efficacy of lubiprostone in opioid-induced constipation.DailyMed (U.S. National Library of Medicine)

• Available human data are insufficient to determine a drug-associated risk; lubiprostone caused fetal loss in guinea pigs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; monitor breastfed infants for diarrhea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Lubiprostone: Locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering serum sodium and potassium, increasing intestinal fluid and motility.