سعر لوكرين 5مجم/مل فيال + 14 سرنجة 2022

Lucrine (AbbVie) leuprolide acetate 5 mg/ml solution for subcutaneous injection in a 2.8 ml multi-dose vial supplied with 14 syringes (a 14-day daily-injection kit): a GnRH agonist that suppresses gonadal sex-hormone production.

• Palliative treatment of advanced prostatic cancer.Population: Adult menDailyMed (U.S. National Library of Medicine)

• Most frequent in the comparative trial versus DES (98 patients): hot flashes (55 reports), ECG changes/ischaemia (19), general pain (13), peripheral oedema (12), asthenia (10), high blood pressure (8); also decreased testicular size, gynaecomastia, impotence, constipation, nausea/vomiting, headache, insomnia, dermatitis, urinary frequency and haematuria.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Transient worsening of bone pain, haematuria or urinary obstruction and temporary lower-limb weakness or paraesthesia in the first week of treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to GnRH, GnRH agonist analogues or any excipient (anaphylactic reactions to GnRH agonists have been reported).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Initial testosterone surge: transient worsening of prostate cancer symptoms or bone pain may occur in the first weeks; isolated ureteral obstruction and spinal cord compression (possibly leading to paralysis) have occurred. Observe patients with vertebral metastases or urinary obstruction closely in the first weeks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperglycaemia and increased risk of diabetes have been reported with GnRH agonists in men; monitor blood glucose and/or HbA1c periodically.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased risk of myocardial infarction, sudden cardiac death and stroke has been reported with GnRH agonists in men; monitor for cardiovascular disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Drugs that prolong the QT intervalAndrogen deprivation therapy may prolong QT; weigh benefits and risks in patients taking QT-prolonging drugs. No pharmacokinetic interaction studies; interactions via cytochrome P450 are not expected (peptide degraded by peptidases).DailyMed (U.S. National Library of Medicine)

• Based on animal findings and mechanism of action, leuprolide acetate may cause fetal harm; no human pregnancy data. Advise pregnant patients and females of reproductive potential of the risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk or effects on the breastfed child; decide whether to discontinue breastfeeding or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Leuprorelin acetate: Synthetic nonapeptide GnRH analogue; after an initial rise in LH, FSH and sex steroids, continuous daily administration down-regulates pituitary GnRH receptors and reduces testosterone to castrate levels (oestrogens to post-menopausal levels) within 2 to 4 weeks.