سعر لوميبروكس بلس قطرة عين 3مل 2022

Lumiprox Plus (Eva Pharma) bimatoprost + timolol ophthalmic solution, 3 ml: a fixed combination of a prostamide and a non-selective beta-blocker used to lower intraocular pressure. Strengths are not stated by the Egyptian directories.

• Reduction of intraocular pressure in adults with open-angle glaucoma or ocular hypertension insufficiently responsive to topical beta-blockers or prostaglandin analogues.Population: Adultselectronic medicines compendium (emc), UK

• Most common: conjunctival hyperaemia (about 26%, mostly trace to mild; led to discontinuation in 1.5%). Common: headache, punctate keratitis, corneal erosion, burning, irritation, eye pruritus, stinging, foreign body sensation, dry eye, eyelid erythema, eye pain, photophobia, visual disturbance, growth of eyelashes. Not known: insomnia, dysgeusia, dizziness, hypersensitivity including angioedema.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to the active substances or any excipient.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Reactive airway disease including bronchial asthma or a history of asthma; severe chronic obstructive pulmonary disease.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Sinus bradycardia, sick sinus syndrome, sino-atrial block, second- or third-degree AV block not controlled with a pacemaker; overt cardiac failure; cardiogenic shock.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Timolol is absorbed systemically: cardiovascular, respiratory (including fatal bronchospasm in asthma) and other beta-blocker reactions may occur; caution in cardiovascular disease, first-degree heart block, severe peripheral circulatory disorders, mild/moderate COPD, labile diabetes (masked hypoglycaemia), hyperthyroidism (masked signs) and before surgical anaesthesia.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Bimatoprost component: eyelash growth, darkening of eyelid skin and increased (likely permanent) iris pigmentation; cystoid macular oedema reported. Contains benzalkonium chloride.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Patients with a history of atopy or severe anaphylaxis may be more reactive to allergens and unresponsive to usual adrenaline doses while on beta-blockers; choroidal detachment reported after filtration surgery with aqueous suppressants.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Oral calcium channel blockers, guanethidine, beta-blockers, parasympathomimetics, antiarrhythmics (including amiodarone), digitalis glycosidesPotential additive effects resulting in hypotension and/or marked bradycardia.electronic medicines compendium (emc), UK
• CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine)Potentiated systemic beta-blockade (decreased heart rate, depression) reported with timolol.electronic medicines compendium (emc), UK
• Adrenaline (epinephrine)Mydriasis occasionally reported with ophthalmic beta-blockers and adrenaline.electronic medicines compendium (emc), UK

• No adequate data for the combination in pregnancy; should not be used unless clearly necessary. Oral beta-blockers have been associated with intrauterine growth retardation.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Should not be used by breastfeeding women (bimatoprost excreted in rat milk; beta-blockers excreted in human milk).International label, equivalent formulation · electronic medicines compendium (emc), UK

• Bimatoprost: Increases aqueous humour outflow through the trabecular meshwork and uveoscleral pathway.
• Timolol: Non-selective beta-blocker that lowers intraocular pressure by reducing aqueous humour formation.