سعر ليسودرن 500مجم 100 قرص 2026

Lysodren 500 mg mitotane tablets, bottle of 100; listed in Egyptian price directories as an illegal (unregistered) import with no price.

• Inoperable, functional or nonfunctional adrenocortical carcinoma.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Reported reactions include anorexia, nausea, vomiting, diarrhoea, dizziness, vertigo, confusion, ataxia, rash, leukopenia, anaemia, thrombocytopenia, hepatitis, gynaecomastia, hypothyroidism and hypercholesterolaemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• None listed in the US label.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: risk of adrenal crisis in shock, severe trauma or infection; temporarily stop mitotane and give exogenous steroids, and withhold before planned surgery.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Adrenal insufficiency: replace glucocorticoids and mineralocorticoids as needed (high replacement doses may be required).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• CNS toxicity (sedation, lethargy, vertigo), especially with plasma levels above 20 mg/L; may impair driving.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• SpironolactoneMay block the action of mitotane; avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• CYP3A substratesMitotane is a strong CYP3A inducer and lowers their levels; avoid where small changes cause therapeutic failure, or adjust the substrate dose.DailyMed (U.S. National Library of Medicine)
• Hormonal contraceptivesMay be rendered ineffective; avoid and use non-hormonal contraception.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm: postmarketing cases of preterm birth and early pregnancy loss; no animal reproduction studies. Verify pregnancy status before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Mitotane is excreted in human milk; do not breastfeed during treatment and while plasma levels remain detectable.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Mitotane: Adrenolytic agent that acts on the adrenal cortex (mitochondrial damage and inhibition of steroidogenesis); it also strongly induces CYP3A (US label).