سعر ماجنابيوتيك 312.5مجم/5مل شراب 80مل 2022

Magnabiotic 312.5mg/5ml susp. 80ml: Sedico powder for oral suspension (80 ml bottle) of amoxicillin + clavulanic acid, 312.5 mg per 5 ml in total, an oral beta-lactam/beta-lactamase inhibitor antibiotic.

• Infections due to susceptible beta-lactamase-producing isolates: lower respiratory tract infections, acute bacterial otitis media and sinusitis (H. influenzae, M. catarrhalis), skin and skin structure infections (S. aureus, E. coli, Klebsiella) and urinary tract infections (E. coli, Klebsiella, Enterobacter).Population: Adults and paediatric patientsDailyMed (U.S. National Library of Medicine)

• Most frequent: diarrhoea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%) and vaginitis (1%); less than 3% discontinued; diarrhoea increases with higher doses.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity reactions (e.g. anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactams (penicillins, cephalosporins).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Previous history of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanate.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions; enquire about previous penicillin, cephalosporin or other allergies before starting and discontinue if an allergic reaction occurs. Severe cutaneous adverse reactions and drug-induced enterocolitis syndrome are also listed as warnings.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction including hepatitis and cholestatic jaundice, usually reversible but deaths reported; monitor hepatic function in hepatic impairment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea may occur, even more than 2 months after treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of amoxicillin (not clavulanate), increasing and prolonging amoxicillin levels; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulants (e.g. warfarin)Abnormal prolongation of prothrombin time (increased INR) reported; monitor and adjust the anticoagulant dose if needed.DailyMed (U.S. National Library of Medicine)
• AllopurinolIncreased incidence of rashes with amoxicillin.DailyMed (U.S. National Library of Medicine)

• Animal reproduction studies showed no evidence of fetal harm, but there are no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is excreted in human milk; use by nursing mothers may lead to sensitisation of infants, so exercise caution.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Semisynthetic penicillin that inhibits penicillin-binding proteins in bacterial peptidoglycan (cell wall) synthesis, leading to cell lysis; it is degraded by beta-lactamases.
• Clavulanic acid: Beta-lactam structurally related to penicillins that inactivates some beta-lactamase enzymes, protecting amoxicillin from degradation and extending its spectrum; no clinically useful antibacterial effect alone.