سعر موزانجليك 21 قرص 2025

Mozanglic tablets (Acdima International Trading, Egypt): combined oral contraceptive containing ethinylestradiol 0.03 mg and drospirenone 3 mg per tablet; pack of 21 tablets.

• Oral contraception (prevention of pregnancy).Population: Women of reproductive ageelectronic medicines compendium (emc), UK
• Prevention of pregnancy in females of reproductive potential.Population: Females of reproductive potentialDailyMed (U.S. National Library of Medicine)

• Most common (at least 2%): premenstrual syndrome (13.2%), headache/migraine (10.7%), breast pain/tenderness (8.3%), nausea/vomiting (4.5%), abdominal pain (2.3%) and mood changes (2.3%). Serious reactions included depression, pulmonary embolism, toxic skin eruption and uterine leiomyoma.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Presence or risk of venous thromboembolism (current or past VTE, hereditary or acquired predisposition, major surgery with prolonged immobilisation, multiple risk factors) and presence or risk of arterial thromboembolism; severe hepatic disease; severe renal insufficiency or acute renal failure (see full SmPC section 4.3).International label, same formulation · electronic medicines compendium (emc), UK
• Renal impairment; adrenal insufficiency; high risk of arterial or venous thrombotic disease (e.g. smokers over 35, DVT/PE, cerebrovascular or coronary disease, thrombogenic valvular/rhythm disease, hypercoagulopathies, uncontrolled hypertension, diabetes with vascular disease, migraine with focal neurological symptoms or migraine if over 35); undiagnosed abnormal uterine bleeding; breast cancer; liver tumour or liver disease; use of hepatitis C regimens containing ombitasvir/paritaprevir/ritonavir with or without dasabuvir.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: cigarette smoking increases the risk of serious cardiovascular events from combined oral contraceptive use, especially in women over 35 and with the number of cigarettes smoked; women over 35 who smoke should not use it.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Drospirenone-containing combined pills may carry a higher risk of venous thromboembolism than those containing levonorgestrel (studies ranged from no increase to a three-fold increase); stop if an arterial or venous thrombotic event occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia: 3 mg drospirenone has anti-mineralocorticoid activity comparable to 25 mg spironolactone; check serum potassium in the first treatment cycle in women on long-term drugs that may raise potassium.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A4 enzyme inducers (e.g. phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, rifampicin, St John's wort)May decrease contraceptive effectiveness or increase breakthrough bleeding; use a back-up or alternative method with enzyme inducers.DailyMed (U.S. National Library of Medicine)
• LamotrigineCombined oral contraceptives significantly decrease lamotrigine concentrations, which may reduce seizure control; lamotrigine dose adjustment may be needed.DailyMed (U.S. National Library of Medicine)
• Ombitasvir/paritaprevir/ritonavir with or without dasabuvirALT elevations above 5 times ULN were more frequent with ethinyl estradiol-containing products; discontinue the pill before starting this hepatitis C regimen.DailyMed (U.S. National Library of Medicine)

• Not indicated during pregnancy; withdraw immediately if pregnancy occurs. Epidemiological studies show neither increased birth-defect risk after use before pregnancy nor a teratogenic effect after inadvertent use in pregnancy; data specific to this combination in pregnancy are too limited for conclusions.International label, same formulation · electronic medicines compendium (emc), UK
• No use for contraception in pregnancy; discontinue during pregnancy. Studies have not found increased risk of genital or non-genital birth defects after exposure before conception or in early pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Combined pills may reduce the quantity and change the composition of breast milk; generally not recommended until the child is completely weaned. Small amounts of steroids may pass into milk.International label, same formulation · electronic medicines compendium (emc), UK

• Ethinylestradiol:
• Drospirenone: As part of the combined pill, contraception is achieved primarily by suppressing ovulation; drospirenone also has anti-mineralocorticoid activity (US label).