سعر ميرين 100مجم 30 قرص 2022

Myrin 100 mg tablets (Lipomed AG; distributed by Egyptian Pharmaceutical Trading Company): thalidomide, an immunomodulatory agent; pack of 30 tablets (3 strips).

• In combination with melphalan and prednisone, first-line treatment of untreated multiple myeloma in patients aged 65 years or older or ineligible for high-dose chemotherapy.Population: Adultselectronic medicines compendium (emc), UK
• Thalomid (US): with dexamethasone for newly diagnosed multiple myeloma; acute treatment and maintenance for cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL).DailyMed (U.S. National Library of Medicine)

• Very common with melphalan/prednisone: neutropenia, leukopenia, anaemia, lymphopenia, thrombocytopenia, peripheral neuropathy, tremor, dizziness, paraesthesia, dysaesthesia, somnolence, constipation and peripheral oedema.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to thalidomide or excipients; pregnancy; women of childbearing potential unless all Pregnancy Prevention Programme conditions are met; male patients unable to follow contraceptive measures.International label, same formulation · electronic medicines compendium (emc), UK

• Powerful human teratogen: the Pregnancy Prevention Programme (effective contraception from 4 weeks before to 4 weeks after treatment, pregnancy tests every 4 weeks, condoms for male patients) is mandatory; no blood or semen donation during and 7 days after treatment.International label, same formulation · electronic medicines compendium (emc), UK
• Increased risk of venous and arterial thromboembolism, greatest in the first 5 months; thromboprophylaxis for at least the first 5 months is recommended.International label, same formulation · electronic medicines compendium (emc), UK
• Peripheral neuropathy (very common, potentially irreversible); neutropenia and thrombocytopenia; syncope, bradycardia and AV block; severe skin reactions (SJS, TEN, DRESS); somnolence; viral reactivation (herpes zoster, HBV); PML; increased AML/MDS in MPT-treated patients.International label, same formulation · electronic medicines compendium (emc), UK

• Sedatives (anxiolytics, hypnotics, antipsychotics, H1 antihistamines, opiates, barbiturates, alcohol)Thalidomide may enhance their sedative effect; use caution.electronic medicines compendium (emc), UK
• Bradycardic drugs (beta blockers, anticholinesterases, drugs inducing torsade de pointes)Caution because of additive bradycardic potential.electronic medicines compendium (emc), UK
• Drugs causing peripheral neuropathy (e.g. vincristine, bortezomib)Use with caution.electronic medicines compendium (emc), UK

• Contraindicated in pregnancy and in women of childbearing potential unless all Pregnancy Prevention Programme conditions are met; powerful human teratogen causing severe, life-threatening birth defects in about 30% of exposures.International label, same formulation · electronic medicines compendium (emc), UK
• Thalomid (US): can cause embryo-fetal harm and is contraindicated during pregnancy; even a single dose can cause severe birth defects.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Unknown whether excreted in human milk; excreted in animal milk; breastfeeding should be discontinued during treatment.International label, same formulation · electronic medicines compendium (emc), UK

• Thalidomide: Immunomodulatory, anti-inflammatory and potential anti-neoplastic activities, possibly via suppression of excessive TNF-alpha production, down-modulation of leukocyte adhesion molecules and anti-angiogenic activity; also a centrally active hypnotic sedative (UK SmPC).