سعر ناتريستازين اس ار 1.5مجم 30 اقراص 2023

Natristazen SR 1.5 mg 30 f.c. tablets (indapamide 1.5 mg prolonged-release), Medizen Pharmaceutical Industries: thiazide-like diuretic for essential hypertension.

• Essential hypertension in adults.Population: Adultselectronic medicines compendium (emc), UK

• Most commonly reported: hypokalaemia, hypersensitivity reactions (mainly dermatological, in predisposed subjects) and maculopapular rashes. Uncommon: hyponatraemia, vomiting. Not known: syncope, acute angle-closure glaucoma, choroidal effusion, torsades de pointes.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to indapamide, other sulfonamides or any excipient; severe renal failure; hepatic encephalopathy or severe impairment of liver function; hypokalaemia.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Photosensitivity reactions have been reported; stop treatment if they occur. Contains lactose (UK product): not for hereditary galactose intolerance, total lactase deficiency or glucose-galactose malabsorption.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Hyponatraemia (sometimes serious) and hypokalaemia are key risks; hypokalaemia may cause muscle disorders and rhabdomyolysis and, with long QT or bradycardia, potentially fatal torsades de pointes. Risk groups: elderly, malnourished/polymedicated, cirrhotic, coronary or heart-failure patients.International label, equivalent formulation · electronic medicines compendium (emc), UK

• LithiumCombination not recommended: increased plasma lithium with signs of overdose (decreased urinary lithium excretion); if a diuretic is necessary, monitor plasma lithium carefully and adjust the dose.electronic medicines compendium (emc), UK
• Torsades de pointes-inducing drugs (class Ia and III antiarrhythmics, some antipsychotics, erythromycin IV, methadone, moxifloxacin and others)Increased risk of ventricular arrhythmias, particularly torsades de pointes (hypokalaemia is a risk factor); correct hypokalaemia before combining and monitor electrolytes and ECG.electronic medicines compendium (emc), UK

• Limited data (<300 pregnancy outcomes); prolonged thiazide exposure in the third trimester can reduce maternal plasma volume and uteroplacental blood flow (foeto-placental ischaemia, growth retardation). As a precaution, preferable to avoid during pregnancy.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Insufficient information on excretion in human milk; sulfonamide hypersensitivity and hypokalaemia might occur in the infant and thiazide-like diuretics may reduce or suppress lactation; a risk cannot be excluded.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Indapamide: Inhibits sodium reabsorption in the cortical diluting segment, increasing urinary sodium and chloride excretion (and to a lesser extent potassium and magnesium); antihypertensive action linked to improved arterial compliance and reduced peripheral resistance.