سعر Amlosterolen 10/40 mg 14 film-coated tablets 2026

Fixed-dose combination film-coated tablet (Medizen Pharmaceutical Industries) containing amlodipine 10 mg and atorvastatin 40 mg; 14 tablets.

• Patients for whom treatment with both amlodipine (hypertension, chronic stable or vasospastic angina, angiographically documented CAD) and atorvastatin (to reduce cardiovascular risk and as an adjunct to diet to lower LDL-C in hyperlipidaemia) is appropriate.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Amlodipine: dose-related oedema. Atorvastatin: nasopharyngitis, arthralgia, diarrhoea, pain in extremity, urinary tract infection.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Acute liver failure or decompensated cirrhosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to amlodipine, atorvastatin or any excipient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis (risk increased with higher atorvastatin doses, age 65 or more, renal impairment, hypothyroidism and certain interacting drugs); immune-mediated necrotizing myopathy has been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction: consider liver enzyme testing before initiation and when clinically indicated.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased angina or myocardial infarction may occur on starting or increasing amlodipine, especially in severe obstructive coronary artery disease; symptomatic hypotension is possible.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, HIV/HCV protease inhibitors)Increase atorvastatin and amlodipine exposure and myopathy risk; avoid or limit atorvastatin dose per label.DailyMed (U.S. National Library of Medicine)
• Cyclosporine, gemfibrozil, tipranavir plus ritonavir, glecaprevir plus pibrentasvirConcomitant use is not recommended (increased risk of myopathy/rhabdomyolysis).DailyMed (U.S. National Library of Medicine)
• Grapefruit juiceAvoid large quantities (more than 1.2 litres daily).DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognised (atorvastatin component); alternatively consider the ongoing therapeutic needs of the individual patient.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.
• Atorvastatin: Inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis.