سعر نيبسين 20مجم/2مل فيال 2022

Nebcin 20mg/2ml vial: tobramycin (as sulfate) 20 mg/2 ml solution for injection, single vial (Eli lilly); parenteral aminoglycoside antibiotic for serious Gram-negative infections.

• Serious bacterial infections caused by susceptible organisms: septicaemia (neonates, children, adults), lower respiratory tract infections, serious CNS infections (meningitis), intra-abdominal infections including peritonitis, skin/bone/skin-structure infections, and complicated and recurrent urinary tract infections.Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)

• Neurotoxicity (dizziness, vertigo, tinnitus, roaring in the ears, hearing loss) and nephrotoxicity (rising BUN/creatinine, oliguria, cylindruria, proteinuria) are the main adverse effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any aminoglycoside (cross-sensitivity within the class).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: potential ototoxicity (often irreversible, bilateral hearing loss, vestibular toxicity) and nephrotoxicity, especially with pre-existing renal damage, higher doses or prolonged therapy; avoid prolonged peaks above 12 mcg/mL and troughs above 2 mcg/mL.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Avoid concurrent or sequential neurotoxic/nephrotoxic drugs (other aminoglycosides, cephaloridine, polymyxin B, colistin, cisplatin, vancomycin) and potent diuretics (ethacrynic acid, furosemide); caution in premature/neonatal infants, elderly and dehydrated patients. Contains sodium metabisulfite (sulfite allergic-type reactions). Aminoglycosides can cause fetal harm.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potent diuretics (ethacrynic acid, furosemide)Should not be given concurrently; may enhance ototoxicity and alter aminoglycoside concentrations.DailyMed (U.S. National Library of Medicine)
• Other neurotoxic/nephrotoxic antibiotics and cisplatin, vancomycinConcurrent and sequential use should be avoided.DailyMed (U.S. National Library of Medicine)

• Aminoglycosides can cause fetal harm in pregnancy: they cross the placenta and total irreversible bilateral congenital deafness has been reported with streptomycin; if used in pregnancy the patient should be told of the potential hazard.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Tobramycin: Bactericidal aminoglycoside that inhibits bacterial protein synthesis; active against many Gram-negative organisms including Pseudomonas aeruginosa, and Staphylococcus aureus.