سعر نيوروتوب 400 مجم 100 قرص 2024

Carbamazepine 400 mg tablets, pack of 100 (Gerot Pharma / B.P. Pharma), antiepileptic.

• Epilepsy: partial seizures (simple or complex, with or without secondary generalization); generalized tonic-clonic seizures; mixed forms of these seizures. Suitable for monotherapy and combination therapy. Not normally effective in absence (petit mal) or myoclonic seizures.Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)
• Acute mania and maintenance treatment of bipolar affective disorders to prevent or attenuate recurrence.Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)
• Idiopathic trigeminal neuralgia and trigeminal neuralgia secondary to multiple sclerosis; idiopathic glossopharyngeal neuralgia.Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)

• Very common/common especially at start or high dose: dizziness, ataxia, drowsiness, exhaustion, diplopia, nausea, vomiting, allergic skin reactions; leucopenia; elevated GGT (enzyme induction). Rare/very rare: SJS/TEN, agranulocytosis, aplastic anaemia, hepatitis, hyponatraemia/SIADH, cardiac conduction disturbances.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)

• Known hypersensitivity to carbamazepine, oxcarbazepine or structurally related drugs (e.g. tricyclic antidepressants), or to any excipient.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)
• Atrioventricular (AV) block; history of bone marrow depression; history of acute intermittent porphyria.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)
• Concomitant use with MAO inhibitors is not recommended; discontinue MAOIs at least 2 weeks before starting carbamazepine.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)

• Serious dermatologic reactions (SJS/TEN) and haematologic toxicity (agranulocytosis, aplastic anaemia) have been associated with carbamazepine; discontinue if significant bone-marrow depression or severe cutaneous reaction occurs. Baseline and periodic CBC and liver tests are required.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)
• May exacerbate absence or myoclonic seizures; use caution in mixed seizure types including absences. Abrupt withdrawal may precipitate seizures.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)
• Enzyme inducer: may reduce efficacy of oral contraceptives and many other drugs; advise alternative contraception. Avoid grapefruit juice and alcohol.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)

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• Definite evidence of risks to the human fetus (neural tube defects including spina bifida, craniofacial and cardiovascular malformations). Use lowest effective dose, preferably monotherapy; folic acid before/during pregnancy; vitamin K in late pregnancy and to neonate. Do not withdraw necessary antiepileptic therapy abruptly.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)
• Carbamazepine is excreted in breast milk at approximately 25–60% of plasma concentrations. Benefits of breastfeeding generally outweigh risks; discontinue breastfeeding if poor weight gain, excessive drowsiness or allergic skin reaction in the infant.International label, same product · Gerot Pharmazeutika / MedicaRCP Neurotop PIL (EN)

• Carbamazepine: Prolongs the inactivated state of voltage-gated neuronal sodium channels, reducing high-frequency neuronal firing.