سعر نيفيلوب املو 5/5مجم 30 قرص 2022

Nevilob Amlo 5/5 mg tablets (Marcyrl): fixed-dose combination of nebivolol hydrochloride 5 mg and amlodipine 5 mg for hypertension.

• Antihypertensive fixed-dose combination (nebivolol + amlodipine) for blood-pressure control — component indications support use in hypertension; Egyptian combination SmPC not opened.MHRA / eMC, DailyMed / FDA

• Apply nebivolol contraindications (hepatic impairment, acute HF, severe bradycardia/AV block, asthma, etc. per UK Nebilet) and amlodipine contraindications (severe hypotension, obstruction of LV outflow, cardiogenic shock) — confirm on combination label.General active-ingredient information · MHRA / eMC

• Combination of nebivolol with dihydropyridine CCBs may increase hypotension risk; avoid abrupt beta-blocker withdrawal; monitor for oedema (amlodipine) and bradycardia (nebivolol).General active-ingredient information · MHRA / eMC

• Nebivolol: avoid in pregnancy unless clearly necessary (UK Nebilet). Amlodipine: limited human data; use only if clearly needed. Combination pregnancy advice must follow the local FDC label.General active-ingredient information · MHRA / eMC

• Nebivolol hydrochloride: Beta-adrenergic receptor blocker; antihypertensive mechanism not definitively established (reduced heart rate and contractility, reduced sympathetic outflow, renin suppression, vasodilation) per the US BYSTOLIC label.
• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.