سعر نيكسيكيور 20مجم 14 قرص 2024

Nexicure 20 mg film-coated tablets × 14 (Atco Pharma / Zeta Pharm): esomeprazole PPI for acid-related disorders.

• Healing and maintenance of erosive esophagitis; symptomatic GERD; risk reduction of NSAID-associated gastric ulcer; H. pylori eradication (triple therapy); pathological hypersecretory conditions including Zollinger-Ellison syndrome (US Nexium USPI indications — summary).Population: Adults (paediatric age bands per USPI)DailyMed (NLM)

• Known hypersensitivity to substituted benzimidazoles or any component of the formulation; hypersensitivity reactions may include anaphylaxis, angioedema, bronchospasm, acute tubulointerstitial nephritis and urticaria (US Nexium USPI).International label, equivalent formulation · DailyMed (NLM)

• Gastric malignancy may be masked; acute tubulointerstitial nephritis; Clostridioides difficile-associated diarrhea; bone fracture with long-term/high-dose PPI; severe cutaneous adverse reactions; cutaneous/systemic lupus erythematosus; interaction with clopidogrel; B12 deficiency; hypomagnesemia; fundic gland polyps — see full US Nexium Warnings (summary).International label, equivalent formulation · DailyMed (NLM)

• ClopidogrelMajorAvoid concomitant use; esomeprazole (CYP2C19 inhibitor) reduces activation of clopidogrel (US Nexium USPI).DailyMed (NLM)
• Methotrexate (high dose)ModerateConcomitant PPIs may elevate/prolong methotrexate levels; consider temporary PPI withdrawal (US Nexium USPI).DailyMed (NLM)

• No adequate well-controlled studies with esomeprazole in pregnant women; available epidemiologic data with first-trimester omeprazole have not demonstrated an increased risk of major congenital malformations (US Nexium USPI — FDA PLLR summary).International label, equivalent formulation · DailyMed (NLM)
• Limited data suggest omeprazole may be present in human milk; no clinical data on effects of esomeprazole on the breastfed infant. Weigh benefits of breastfeeding against maternal need (US Nexium USPI).International label, equivalent formulation · DailyMed (NLM)

• Esomeprazole: S-isomer of omeprazole; inhibits the gastric H+/K+-ATPase (proton pump) of parietal cells, suppressing basal and stimulated acid secretion (US NEXIUM label).