سعر ازجوفانس 40مجم 7 كبسولات 2024

Omeprazole 40 mg + sodium bicarbonate 1100 mg immediate-release capsules, 7 capsules; proton pump inhibitor with antacid buffer (Sabaa for APIC, Egypt).

• Short-term treatment of active duodenal ulcerPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Short-term treatment (4-8 weeks) of active benign gastric ulcerPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of heartburn and other symptoms associated with GERD (up to 4 weeks)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (more than 2%): headache, abdominal pain, nausea, diarrhea, vomiting and flatulence.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to any component of the formulation (reactions may include anaphylaxis, angioedema, bronchospasm, acute tubulointerstitial nephritis, urticaria); patients receiving rilpivirine-containing products.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sodium bicarbonate content: consider the sodium load in patients on sodium-restricted diets or at risk of congestive heart failure; avoid in Bartter's syndrome, hypokalemia, hypocalcemia and acid-base disorders; chronic use with calcium or milk may cause milk-alkali syndrome, and chronic bicarbonate use may cause systemic alkalosis, edema and weight gain.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• PPI class warnings: symptomatic response does not exclude gastric malignancy; acute tubulointerstitial nephritis; Clostridioides difficile-associated diarrhea; osteoporosis-related fractures with long-term or high-dose use; severe cutaneous adverse reactions; cutaneous and systemic lupus erythematosus; vitamin B12 deficiency with long-term use; hypomagnesemia; fundic gland polyps; interference with chromogranin A tests.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Rilpivirine-containing productsReduced rilpivirine exposure and loss of virologic response; contraindicated.DailyMed (U.S. National Library of Medicine)
• ClopidogrelOmeprazole reduces the antiplatelet activity of clopidogrel; avoid concomitant use and consider alternative anti-acid therapy.DailyMed (U.S. National Library of Medicine)
• Methotrexate (especially high dose)PPIs may elevate and prolong methotrexate levels; consider temporary withdrawal of the PPI.DailyMed (U.S. National Library of Medicine)

• No adequate and well-controlled studies with the combination in pregnant women. Available epidemiologic data fail to demonstrate an increased risk of major congenital malformations or other adverse pregnancy outcomes with first-trimester omeprazole use.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Published data suggest both omeprazole and sodium bicarbonate are present in human milk; no data on effects on the breastfed infant or milk production. Weigh breastfeeding benefits against the mother's need for the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Omeprazole: Suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase (proton pump) at the secretory surface of the gastric parietal cell (US Zegerid label).
• Sodium bicarbonate: Raises gastric pH, protecting acid-labile omeprazole from degradation in the stomach so it can be absorbed without an enteric coating (US Zegerid label).