سعر اتميبرازول 20 مجم 20 كبسولة 2022

Esomeprazole 20 mg capsules, a proton pump inhibitor, listed in Egypt under ATCO Pharma / ATM Pharmaceutical Industries; pack of 20 capsules.

• Healing of erosive esophagitisPopulation: Adults and pediatric patients 1 month and older (strength/form by age)DailyMed (U.S. National Library of Medicine)
• Maintenance of healing of erosive esophagitisPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of symptomatic gastroesophageal reflux disease (GERD)Population: Adults and pediatric patients 1 year and olderDailyMed (U.S. National Library of Medicine)

• Adults (erosive esophagitis trials): most frequent adverse reactions (at least 1%) were headache (5.5% with 20 mg, 5% with 40 mg) and diarrhoea; nausea, flatulence, abdominal pain, constipation and dry mouth were also reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to substituted benzimidazoles or any component (reactions may include anaphylaxis, angioedema, bronchospasm, acute tubulointerstitial nephritis, urticaria).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Contraindicated with rilpivirine-containing products.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Symptomatic response does not exclude gastric malignancy; consider further evaluation (endoscopy in older patients) if response is suboptimal or relapse is early.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Acute tubulointerstitial nephritis may occur at any time: discontinue and evaluate.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Increased risk of Clostridioides difficile-associated diarrhoea and of osteoporosis-related hip, wrist or spine fractures (high-dose, long-term use); use the lowest dose and shortest duration appropriate.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• ClopidogrelEsomeprazole 40 mg reduces the antiplatelet activity of clopidogrel (CYP2C19 inhibition); avoid concomitant use and consider alternative antiplatelet therapy.DailyMed (U.S. National Library of Medicine)
• Rilpivirine, atazanavir, nelfinavir and other antiretroviralsDecreased exposure of some antiretrovirals (rilpivirine contraindicated) or increased exposure of others (e.g. saquinavir); consult the antiretroviral labeling.DailyMed (U.S. National Library of Medicine)
• St John's wort, rifampin (CYP2C19/CYP3A4 inducers)Substantially decrease esomeprazole concentrations; avoid concomitant use.DailyMed (U.S. National Library of Medicine)

• No adequate well-controlled studies in pregnant women; epidemiologic data with first-trimester omeprazole (racemate) do not show an increased risk of major malformations or other adverse outcomes. Animal studies showed dose-dependent embryo-lethality at high omeprazole doses and bone-morphology changes in offspring with dosing through pregnancy and lactation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Limited data suggest omeprazole may be present in human milk; no data on effects on the breastfed infant or milk production; weigh breastfeeding benefits against the mother's need and potential infant risk.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Esomeprazole: S-isomer of omeprazole; after protonation in the parietal-cell acid compartment it forms an active sulphenamide that specifically inhibits the gastric H+/K+-ATPase (proton pump), suppressing basal and stimulated acid secretion (US NEXIUM label).