سعر نيكوتيبان 750مجم 20 اقراص 2022

Nicotinic acid (niacin) 750 mg extended-release film-coated tablets, pack of 20 (Eva Pharma, Egypt); lipid-modifying agent.

• Adjunct to diet to reduce elevated TC, LDL-C, Apo B and TG and increase HDL-C in primary hyperlipidemia and mixed dyslipidemia (also with simvastatin or lovastatin when monotherapy is inadequate); reduce risk of recurrent nonfatal MI in patients with prior MI and hyperlipidemia; with a bile acid resin to slow progression or promote regression of atherosclerosis; adjunct for severe hypertriglyceridemia with pancreatitis risk.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>5% and greater than placebo): flushing, diarrhea, nausea, vomiting, increased cough and pruritus; flushing may be reduced by aspirin pretreatment and slow titration.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Active liver disease or unexplained persistent elevations in hepatic transaminases; active peptic ulcer disease; arterial bleeding; hypersensitivity to niacin or any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Severe hepatic toxicity, including fulminant hepatic necrosis, has occurred when sustained-release niacin was substituted for immediate-release niacin at equivalent doses; use with caution with substantial alcohol use or a history of liver disease. Rhabdomyolysis has been associated with lipid-altering niacin doses (>=1 g/day) combined with statins. Niacin can raise fasting blood glucose (monitor diabetics). Use with caution in unstable angina or acute MI and in renal impairment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Statins (HMG-CoA reductase inhibitors)Increased risk of myopathy/rhabdomyolysis with niacin >=1 g/day; weigh benefits and risks and monitor muscle symptoms.DailyMed (U.S. National Library of Medicine)
• Bile acid sequestrantsHigh niacin-binding capacity; allow 4 to 6 hours (or as long as possible) between the resin and niacin.DailyMed (U.S. National Library of Medicine)

• Older US label (historical Pregnancy Category C): no animal reproduction studies; unknown whether lipid-lowering niacin doses cause fetal harm. Discontinue if a woman treated for primary hyperlipidemia becomes pregnant; for hypertriglyceridemia assess benefits and risks individually. Statins are contraindicated in pregnancy (relevant to combined use).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Niacin is excreted into human milk; because of potential serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Nicotinic acid: Mechanism not well defined; may involve partial inhibition of free fatty acid release from adipose tissue and increased lipoprotein lipase activity.