سعر نيفيدبين 30مجم اس ار 10 كبسولات 2022

Nifedipine 30 mg sustained-release capsules, pack of 10 (Sigma, Egypt); dihydropyridine calcium channel blocker.

• Hypertension in adultsPopulation: Adultselectronic medicines compendium (emc), UK
• Prophylaxis of chronic stable angina pectoris in adultsPopulation: Adultselectronic medicines compendium (emc), UK

• Most adverse effects result from vasodilation; common: oedema (about 9.9%), headache (3.9%), and others such as dizziness, flushing, constipation and malaise; uncommon/rare include allergic reactions, tachycardia, palpitations, hypotension, visual disturbances, gingival hyperplasia; agranulocytosis and leukopenia not known frequency.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Peripheral oedema is the most common, dose-related adverse reaction; headache, flushing and dizziness may also occur.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to nifedipine or other dihydropyridines or excipients; pregnancy, women who may become pregnant, and nursing mothers; clinically significant aortic stenosis, unstable angina, within one month of myocardial infarction, cardiogenic shock; acute angina attacks; secondary prevention of MI; acute porphyria; Kock pouch; concomitant rifampicin; hepatic impairment (long-acting formulation).International label, equivalent formulation · electronic medicines compendium (emc), UK
• Contraindicated in patients with known hypersensitivity to nifedipine.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Caution in hypotension (risk with systolic <90 mmHg), poor cardiac reserve or heart failure, dialysis patients with malignant hypertension and hypovolaemia; diabetic therapy may need adjustment; withdraw beta-blockers gradually (nifedipine gives no protection against beta-blocker withdrawal); CYP3A4 inhibitors may raise nifedipine levels - monitor blood pressure.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Excessive hypotension can occur, particularly at initiation or dose increase and with concomitant beta-blockers; monitor blood pressure.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inhibitors (e.g. erythromycin, ritonavir, ketoconazole, nefazodone, fluoxetine, quinupristin/dalfopristin, valproic acid, cimetidine)May increase nifedipine plasma concentrations; monitor blood pressure and consider dose reduction.electronic medicines compendium (emc), UK
• RifampicinContraindicated: enzyme induction may prevent effective nifedipine plasma levels.electronic medicines compendium (emc), UK
• Grapefruit juiceShould not be taken with grapefruit juice (increases nifedipine exposure).electronic medicines compendium (emc), UK

• Contraindicated in pregnancy (Coracten XL SmPC) because animal studies show embryotoxicity and teratogenicity; no adequate studies in pregnant women. Perinatal asphyxia, caesarean delivery, prematurity and growth retardation have been reported (causality unclear); acute pulmonary oedema reported with tocolytic use.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Nifedipine is excreted in breast milk; not recommended during lactation.International label, equivalent formulation · electronic medicines compendium (emc), UK

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