سعر لوديبين 2 مجم 7 أقراص مغلفة 2023

Lodipine 2mg 7 f.c.tab: lacidipine 2 mg film-coated tablets by Egyphar (Egypt); dihydropyridine calcium channel blocker for hypertension.

• Treatment of hypertension, alone or with other antihypertensives (beta-blockers, diuretics, ACE inhibitors)Population: Adultselectronic medicines compendium (emc), UK

• Common: dizziness, headache, palpitations, tachycardia, flushing, abdominal discomfort, nausea, rash, erythema, pruritus, polyuria, asthenia, oedema and raised blood alkaline phosphatase (vasodilatory effects are usually transient). Uncommon: syncope, angina pectoris (aggravation of underlying angina, especially at the start), hypotension, gingival hyperplasia. Rare: angioedema, urticaria, muscle cramps. Very rare: depression, tremor.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to lacidipine or any excipient; aortic stenosis; use during or within one month of a myocardial infarction. Discontinue in patients who develop cardiogenic shock or unstable angina.International label, same formulation · electronic medicines compendium (emc), UK

• Use with great care after a previous allergic reaction to another dihydropyridine (theoretical cross-reactivity). Not established for malignant hypertension; no evidence of benefit for secondary prevention of myocardial infarction.International label, same formulation · electronic medicines compendium (emc), UK
• Caution in patients with pre-existing abnormalities of SA- or AV-node activity, in poor cardiac reserve, and in patients with congenital or acquired QT prolongation or taking drugs that prolong the QT interval.International label, same formulation · electronic medicines compendium (emc), UK

• Other antihypertensives (e.g. diuretics, beta-blockers, ACE inhibitors)Additive blood-pressure-lowering effect.electronic medicines compendium (emc), UK
• CimetidineMay increase plasma lacidipine levels.electronic medicines compendium (emc), UK
• Grapefruit juice and CYP3A4 inhibitors/inducersDo not take with grapefruit juice (bioavailability may be altered). Lacidipine is metabolised by CYP3A4, so significant CYP3A4 inhibitors and inducers (e.g. itraconazole, rifampicin) may interact with its metabolism and elimination.electronic medicines compendium (emc), UK

• No data on safety in human pregnancy. Rat and rabbit data show no teratogenic effect; at doses far above therapeutic, maternal toxicity with increased implantation losses and prolonged, difficult labour (uterine relaxation) were seen. Use in pregnancy only when the potential benefit to the mother outweighs possible adverse effects in the fetus or neonate; consider possible uterine relaxation at term.International label, same formulation · electronic medicines compendium (emc), UK
• Animal milk-transfer studies indicate lacidipine (or metabolites) is likely excreted into breast milk; use during breastfeeding only when the potential benefits for the mother outweigh possible adverse effects.International label, same formulation · electronic medicines compendium (emc), UK

• Lacidipine: Specific, potent calcium antagonist with predominant selectivity for calcium channels in vascular smooth muscle; dilates mainly peripheral arterioles, reducing peripheral vascular resistance and blood pressure.