سعر اوكتوترامادول 50مجم 12 كبسولة 2022

Tramadol 50 mg capsules (Octotramadol, October Pharma, Egypt); pack of 12 capsules.

• Treatment of moderate to severe pain.Population: Adults and adolescents 12 years and overelectronic medicines compendium (emc), UK

• Very common: nausea, dizziness. Common: headache, somnolence, vomiting, constipation, dry mouth, sweating, fatigue. Uncommon/rare: palpitations, tachycardia, postural hypotension, rash, respiratory depression, convulsions, hallucinations, confusion, allergic reactions; not known: serotonin syndrome, hypoglycaemia, drug dependence.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to tramadol or excipients; acute intoxication with alcohol, hypnotics, analgesics, opioids or psychotropics; patients receiving MAO inhibitors or within 14 days of stopping them; epilepsy not adequately controlled; use in narcotic withdrawal treatment.International label, same formulation · electronic medicines compendium (emc), UK

• Concomitant use with benzodiazepines or other sedatives may cause sedation, respiratory depression, coma and death; reserve for patients without alternatives, at the lowest dose and shortest duration.International label, same formulation · electronic medicines compendium (emc), UK
• Convulsions can occur at recommended doses, more so above 400 mg/day or with drugs lowering the seizure threshold; use in epilepsy only if compelling.International label, same formulation · electronic medicines compendium (emc), UK
• Tolerance, dependence and opioid use disorder can develop; abrupt stopping may cause withdrawal; agree goals and a discontinuation plan and monitor for drug-seeking behaviour.International label, same formulation · electronic medicines compendium (emc), UK

• MAO inhibitorsContraindicated; life-threatening CNS, respiratory and cardiovascular interactions cannot be excluded.electronic medicines compendium (emc), UK
• Benzodiazepines, other CNS/respiratory depressants, alcohol, gabapentinoidsAdditive sedation, respiratory depression, hypotension, coma and death.electronic medicines compendium (emc), UK
• SSRIs, SNRIs, tricyclic antidepressants, mirtazapine and other serotonergic drugsRisk of serotonin syndrome; also increased risk of convulsions with seizure-threshold-lowering drugs (including bupropion and antipsychotics).electronic medicines compendium (emc), UK

• Tramadol crosses the placenta and there is inadequate evidence of safety in human pregnancy; it should not be used in pregnant women. Regular use may cause dependence in the fetus and neonatal withdrawal; use during labour may depress neonatal respiration.International label, same formulation · electronic medicines compendium (emc), UK
• Not recommended in nursing women, as tramadol may be secreted in breast milk and cause respiratory depression in the infant.International label, same formulation · electronic medicines compendium (emc), UK

• Tramadol: Centrally acting analgesic; opioid (mu-receptor) activity plus inhibition of neuronal noradrenaline and serotonin reuptake; metabolised by CYP2D6 to an active metabolite (UK SmPC).