سعر اوفيف 150مجم 60 كبسولة 2025

Ofev 150mg 60 cap: Nintedanib 150 mg capsule (Box of 60 capsules) marketed in Egypt by Boehringer Ingelheim.

• Treatment of idiopathic pulmonary fibrosis (IPF) in adultsPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of chronic fibrosing interstitial lung diseases with a progressive phenotype in adultsPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Slowing the rate of decline in pulmonary function in systemic sclerosis-associated interstitial lung disease (SSc-ILD) in adultsPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Diarrhoea is the most frequent adverse reaction (62% vs 18% placebo in IPF trials); others include nausea, abdominal pain, vomiting, liver enzyme elevation, decreased appetite, weight loss, headache and hypertension.International label, same product · DailyMed (U.S. National Library of Medicine)

• The US label lists no contraindications.International label, same product · DailyMed (U.S. National Library of Medicine)

• Elevated liver enzymes and drug-induced liver injury (including fatal cases); gastrointestinal disorders (diarrhoea, nausea, vomiting); embryo-fetal toxicity; arterial thromboembolic events; bleeding risk; gastrointestinal perforation; nephrotic-range proteinuria.International label, same product · DailyMed (U.S. National Library of Medicine)

• P-gp and CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) or inducersKetoconazole increased nintedanib exposure by 60%; monitor tolerability with inhibitors; inducers may reduce exposure.DailyMed (U.S. National Library of Medicine)
• AnticoagulantsVEGFR inhibition may increase bleeding risk; monitor patients on full anticoagulation closely.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm based on animal data (embryo-fetal deaths and structural abnormalities in rats and rabbits); no human data. Verify pregnancy status before treatment and advise effective contraception.International label, same product · DailyMed (U.S. National Library of Medicine)
• No human data; nintedanib is present in rat milk. Breastfeeding is not recommended during treatment.International label, same product · DailyMed (U.S. National Library of Medicine)

• Nintedanib: Small-molecule inhibitor of multiple receptor tyrosine kinases (including VEGFR, FGFR and PDGFR) involved in fibrotic pathways.