سعر اوفيف 100مجم 60 كبسولة 2025

Ofev 100 mg - nintedanib 100 mg capsules, pack of 60, by Boehringer Ingelheim; a tyrosine kinase inhibitor used as an antifibrotic in interstitial lung disease.

• Idiopathic pulmonary fibrosis (IPF)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Chronic fibrosing interstitial lung diseases with a progressive phenotypePopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Slowing the rate of decline in pulmonary function in systemic sclerosis-associated interstitial lung diseasePopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=5%): diarrhoea, nausea, abdominal pain, vomiting, liver enzyme elevation, decreased appetite, headache, weight decrease and hypertension.International label, same product · DailyMed (U.S. National Library of Medicine)

• The US label lists no contraindications.International label, same product · DailyMed (U.S. National Library of Medicine)

• Elevated liver enzymes and drug-induced liver injury, including severe and fatal cases, have occurred; check liver tests before and during treatment.International label, same product · DailyMed (U.S. National Library of Medicine)
• Diarrhoea, nausea and vomiting are frequent; treat early with hydration and antidiarrhoeals and adjust or interrupt dosing as needed.International label, same product · DailyMed (U.S. National Library of Medicine)
• Can cause fetal harm: females of reproductive potential should use highly effective contraception during treatment and for at least 3 months after the last dose; pregnancy test before starting.International label, same product · DailyMed (U.S. National Library of Medicine)

• P-gp and CYP3A4 inhibitors (e.g. ketoconazole, erythromycin)Ketoconazole increased nintedanib exposure by about 60%; monitor tolerability closely.DailyMed (U.S. National Library of Medicine)
• P-gp and CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, St John's wort)Rifampicin decreased nintedanib exposure by about 50%; avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• AnticoagulantsVEGFR inhibition may increase bleeding risk; monitor patients on full anticoagulation closely.DailyMed (U.S. National Library of Medicine)

• Based on animal data and mechanism, can cause fetal harm; embryo-fetal deaths and structural abnormalities occurred in rats and rabbits.International label, same product · DailyMed (U.S. National Library of Medicine)
• No human data; present in rat milk; breastfeeding is not recommended during treatment.International label, same product · DailyMed (U.S. National Library of Medicine)

English text not available for this section.