سعر اسبريت كبسول 267 مجم 270 كبسولة 2026

Pirfenidone 267 mg oral capsules (Esbriet, Roche), pack of 270 capsules.

• Treatment of idiopathic pulmonary fibrosis (IPF).DailyMed (U.S. NLM)

• Most common adverse reactions (10% or more): nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, decreased appetite, GERD, sinusitis, insomnia, weight decreased and arthralgia.International label, same product · DailyMed (U.S. NLM)

• Elevated liver enzymes and drug-induced liver injury, including fatal cases, have occurred; obtain liver tests before treatment, monthly for the first 6 months and every 3 months thereafter, and adjust or discontinue as needed.International label, same product · DailyMed (U.S. NLM)
• Photosensitivity and rash: avoid or minimize sun exposure and sunlamps, use sunscreen (SPF 50) and protective clothing; severe cutaneous adverse reactions including SJS/TEN and DRESS; gastrointestinal disorders (nausea, vomiting, diarrhea, dyspepsia, GERD, abdominal pain) may require dose reduction or interruption.International label, same product · DailyMed (U.S. NLM)

• Fluvoxamine and other strong CYP1A2 inhibitorsMarkedly increase pirfenidone exposure; discontinue fluvoxamine before starting, or reduce pirfenidone to 267 mg three times daily.DailyMed (U.S. NLM)
• Ciprofloxacin (moderate CYP1A2 inhibitor)At ciprofloxacin 750 mg twice daily, reduce pirfenidone to 534 mg three times daily; use moderate/strong inhibitors of CYP1A2 and other CYP enzymes together with caution.DailyMed (U.S. NLM)
• CYP1A2 inducers and cigarette smokingDecrease pirfenidone exposure and may reduce efficacy; avoid strong CYP1A2 inducers and stop smoking.DailyMed (U.S. NLM)

• No adequate data in pregnant women; pirfenidone was not teratogenic in animal reproduction studies.International label, same product · DailyMed (U.S. NLM)
• No information on presence in human milk or effects on the breastfed infant; pirfenidone and/or metabolites are excreted in the milk of lactating rats.International label, same product · DailyMed (U.S. NLM)

• Pirfenidone: The mechanism of action in IPF has not been established (US Esbriet label).