سعر بيرفينكس 200مجم 30 قرص 2023

Pirfenex (pirfenidone) 200 mg tablets, pack of 30, by Cipla Ltd; antifibrotic agent.

• Treatment of idiopathic pulmonary fibrosis (IPF).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Elevated liver enzymes and drug-induced liver injury, including fatal cases; check ALT, AST and bilirubin before starting, monthly for 6 months, then every 3 months.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Photosensitivity reactions and rash; avoid sun exposure, use SPF 50 sunscreen and protective clothing, and avoid other photosensitising drugs.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Fluvoxamine and other strong CYP1A2 inhibitorsSignificantly increase pirfenidone exposure; not recommended; if unavoidable, dosage reduction is recommended.DailyMed (U.S. National Library of Medicine)
• Ciprofloxacin (moderate CYP1A2 inhibitor)Increases pirfenidone exposure; dose adjustment per label.DailyMed (U.S. National Library of Medicine)

• Data in pregnant women are insufficient; pirfenidone was not teratogenic in rats and rabbits at up to 3 and 2 times the maximum recommended dose.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• No human data; pirfenidone or metabolites are excreted in rat milk; weigh benefits of breastfeeding against maternal need.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Pirfenidone: Mechanism of action in IPF has not been established (US Esbriet label).