سعر انجوسموث 75مجم 30 قرص 2024

Clopidogrel 75 mg film-coated tablets (P2Y12/ADP receptor antiplatelet), pack of 30 tablets (3 strips), marketed in Egypt by Mash Premiere.

• Acute coronary syndrome (NSTE-ACS: unstable angina/NSTEMI, managed medically or with revascularization; STEMI managed medically), with aspirin, to reduce MI and strokePopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Recent MI, recent stroke or established peripheral arterial disease, to reduce the rate of MI and strokePopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Bleeding is the main adverse reaction: in CURE, major bleeding 3.7% with clopidogrel + aspirin vs 2.7% with placebo + aspirin (mainly gastrointestinal and puncture sites).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity (e.g., anaphylaxis) to clopidogrel or any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: diminished antiplatelet effect in CYP2C19 poor metabolizers (two loss-of-function alleles); consider another P2Y12 inhibitor.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased risk of bleeding.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Premature discontinuation increases cardiovascular event risk; when possible interrupt 5 days before surgery with major bleeding risk and restart as soon as hemostasis is achieved.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Omeprazole, esomeprazole (CYP2C19 inhibitors)Significantly reduce antiplatelet activity; avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• Strong CYP2C19 inducers (e.g., rifampin)Increase active metabolite and bleeding risk; avoid.DailyMed (U.S. National Library of Medicine)
• Repaglinide (CYP2C8 substrate)Repaglinide exposure increased 3.9-5.1-fold; avoid, or limit repaglinide (start 0.5 mg before meals, max 4 mg/day).DailyMed (U.S. National Library of Medicine)

• Available data from published cases and postmarketing surveillance have not identified drug-associated risks of major birth defects or miscarriage; MI and stroke carry risks for mother and fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; present in rat milk; weigh benefits of breastfeeding against maternal need and potential infant effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Clopidogrel: Prodrug converted (mainly via CYP2C19) to an active metabolite that irreversibly blocks the platelet P2Y12 ADP receptor for the platelet lifespan.