سعر اولابكس 5 مجم 2022

Olapex 5 mg film-coated tablets film-coated tablets containing olanzapine 5 mg, an atypical antipsychotic; Egyptian pack of 30 tablets (Multi-Apex Pharmaceutical Industries).

• Schizophrenia.Population: Adults and adolescents 13-17 yearsDailyMed (U.S. National Library of Medicine)
• Acute treatment of manic or mixed episodes of bipolar I disorder and maintenance treatment of bipolar I disorder (monotherapy or with lithium/valproate).Population: Adults (adolescents 13-17 for acute episodes)DailyMed (U.S. National Library of Medicine)

• Most common in adult schizophrenia (oral monotherapy): postural hypotension, constipation, weight gain, dizziness, personality disorder and akathisia; in adult bipolar mania: asthenia, dry mouth, constipation, increased appetite, somnolence, dizziness and tremor.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• No contraindications for olanzapine monotherapy in the US label; when combined with fluoxetine, lithium or valproate, the contraindications of those products apply.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: elderly patients with dementia-related psychosis treated with antipsychotics have an increased risk of death; olanzapine is not approved for this use, and cerebrovascular adverse events have been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Metabolic changes (hyperglycemia/diabetes, dyslipidemia, weight gain), neuroleptic malignant syndrome, DRESS, tardive dyskinesia, orthostatic hypotension, seizures, somnolence and impaired judgment, and suicide risk inherent to the illness require attention.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Carbamazepine and other CYP1A2 inducers (including smoking)Carbamazepine increases olanzapine clearance by about 50%; CYP1A2 induction lowers olanzapine exposure.DailyMed (U.S. National Library of Medicine)
• Fluvoxamine (CYP1A2 inhibitor)Decreases olanzapine clearance; a lower olanzapine dose may be considered.DailyMed (U.S. National Library of Medicine)
• AlcoholCo-administration potentiated the orthostatic hypotension seen with olanzapine.DailyMed (U.S. National Library of Medicine)

• Published epidemiologic data have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; untreated maternal illness also carries risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Olanzapine is present in human milk; excess sedation, irritability, poor feeding and extrapyramidal symptoms have been reported in exposed infants, who should be monitored.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Olanzapine: The mechanism of action is unclear; efficacy in schizophrenia may be mediated through a combination of dopamine and serotonin type 2 (5-HT2) antagonism (US label).