سعر اوتاثرومب 75مجم 10 اقراص 2026

Clopidogrel 75 mg oral tablets, pack of 10.

• Acute coronary syndrome (NSTE-ACS and STEMI) to reduce the rate of myocardial infarction and stroke, with aspirinPopulation: AdultsDailyMed (US National Library of Medicine)
• Recent myocardial infarction, recent stroke or established peripheral arterial diseasePopulation: AdultsDailyMed (US National Library of Medicine)

• Active pathological bleeding such as peptic ulcer or intracranial haemorrhage.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Hypersensitivity (e.g. anaphylaxis) to clopidogrel or any component of the product.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Boxed warning: diminished antiplatelet effect in CYP2C19 poor metabolizers (two loss-of-function alleles); consider another P2Y12 inhibitor in identified poor metabolizers.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Increases bleeding risk. Premature discontinuation increases cardiovascular event risk; if possible discontinue 5 days before elective surgery with major bleeding risk.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Thrombotic thrombocytopenic purpura (TTP) has been reported; cross-reactivity among thienopyridines has been reported.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Omeprazole or esomeprazole (CYP2C19 inhibitors)Significantly reduce the antiplatelet activity of clopidogrel; avoid concomitant use.DailyMed (US National Library of Medicine)

• Available published and postmarketing data have not identified a drug-associated risk of major birth defects or miscarriage; myocardial infarction and stroke carry maternal and fetal risks.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• No data on presence in human milk; present in rat milk. Weigh breastfeeding benefits against the mother's clinical need.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Clopidogrel: Prodrug converted (mainly via CYP2C19) to an active metabolite that irreversibly blocks the platelet P2Y12 ADP receptor for the platelet lifespan.