سعر سيجاجريل 75مجم 10 اقراص 2026

Sigagrel 75 mg film-coated tablets (clopidogrel) by Sigma (Egypt), a P2Y12 ADP-receptor antiplatelet agent.

• Acute coronary syndrome (non-ST-elevation ACS and STEMI) to reduce MI and stroke.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Recent MI, recent stroke or established peripheral arterial disease to reduce MI and stroke.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Active pathological bleeding such as peptic ulcer or intracranial haemorrhage.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity (e.g. anaphylaxis) to clopidogrel or any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: diminished antiplatelet effect in CYP2C19 poor metabolisers (two loss-of-function alleles); consider another P2Y12 inhibitor.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Avoid concomitant omeprazole or esomeprazole (CYP2C19 inhibition reduces effect).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased bleeding risk; thrombotic thrombocytopenic purpura reported; cross-reactivity among thienopyridines.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Omeprazole / esomeprazole (CYP2C19 inhibitors)Reduce active-metabolite levels and antiplatelet effect; avoid.DailyMed (U.S. National Library of Medicine)
• OpioidsDecreased exposure to clopidogrel; consider a parenteral antiplatelet agent.DailyMed (U.S. National Library of Medicine)
• NSAIDs, warfarin, SSRIs/SNRIs, other antiplatelet agentsIncreased bleeding risk.DailyMed (U.S. National Library of Medicine)

• Published case reports and postmarketing data have not identified drug-associated risks of major birth defects or miscarriage; MI and stroke carry maternal/fetal risks; no fetotoxicity in rats/rabbits at high multiples of the human dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; present in rat milk; weigh benefits of breastfeeding against maternal need for clopidogrel.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Clopidogrel: Prodrug whose active metabolite irreversibly binds the platelet P2Y12 ADP receptor, inhibiting platelet activation and aggregation (US label).