سعر باكليتاكسل اكتافيس 6مجم/مل 100مجم امبول 2022

Paclitaxel actavis 6mg/ml 100mg vial: paclitaxel 6 mg/ml concentrate for intravenous infusion, 100 mg per vial (Actavis > Multipharma). For use under the supervision of an experienced oncologist.

• Advanced carcinoma of the ovary (first-line with cisplatin, and subsequent therapy).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Breast cancer: adjuvant treatment of node-positive disease after doxorubicin-containing chemotherapy, and treatment after failure of combination chemotherapy.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Common effects include anaemia, hair loss, peripheral neuropathy, joint and muscle pain, nausea and vomiting, hypersensitivity reactions and diarrhoea.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to paclitaxel or other drugs formulated in polyoxyl 35 castor oil.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Solid tumours with baseline neutrophils below 1,500 cells/mm3, or AIDS-related Kaposi sarcoma with baseline neutrophils below 1,000 cells/mm3.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Anaphylaxis and severe hypersensitivity reactions occurred in 2-4% of patients in clinical trials; fatal reactions occurred despite premedication.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Substrates, inducers or inhibitors of CYP2C8 and/or CYP3A4Paclitaxel is metabolised mainly by CYP2C8 and partly by CYP3A4; its pharmacokinetics may be altered by drugs affecting these enzymes.DailyMed (U.S. National Library of Medicine)

• Paclitaxel concentrations in animal milk exceeded plasma levels; nursing should be discontinued during paclitaxel therapy.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Paclitaxel: Promotes microtubule assembly from tubulin dimers and stabilises microtubules against depolymerisation, disrupting the microtubule network needed for mitosis.