سعر تاكسول 100مجم/16.7مل فيال 2022

Paclitaxel 100 mg/16.7 mL (6 mg/mL) concentrate for IV infusion vial (taxane antineoplastic), Bristol-Myers Squibb, Egyptian market.

• Advanced ovarian carcinoma (first-line with cisplatin, and subsequent therapy); adjuvant node-positive breast cancer after doxorubicin-containing chemotherapy; metastatic breast cancer after failure of combination chemotherapy; non-small cell lung cancer with cisplatin; second-line AIDS-related Kaposi sarcoma.DailyMed (US National Library of Medicine)

• History of hypersensitivity to paclitaxel or drugs formulated in polyoxyl 35 castor oil; baseline neutrophils < 1,500 cells/mm3 in solid tumors (< 1,000 cells/mm3 in AIDS-related Kaposi sarcoma).International label, same formulation · DailyMed (US National Library of Medicine)

• Boxed warning: administer under supervision of an experienced oncologist; anaphylaxis and severe hypersensitivity in 2-4% of patients (fatal despite premedication); dose-dependent bone marrow suppression (mainly neutropenia) is dose-limiting.International label, same formulation · DailyMed (US National Library of Medicine)
• Contains dehydrated alcohol 396 mg/mL; myelotoxicity may be exacerbated with total bilirubin > 2 x ULN.International label, same formulation · DailyMed (US National Library of Medicine)

• Paclitaxel can cause fetal harm when administered to a pregnant woman (embryo- and fetotoxicity in animal studies).International label, same formulation · DailyMed (US National Library of Medicine)
• Unknown whether excreted in human milk (high milk levels in rats); the older-format US label advises discontinuing nursing during therapy.International label, same formulation · DailyMed (US National Library of Medicine)

• Paclitaxel: Binds beta-tubulin and promotes polymerization into stable non-functional microtubules, inhibiting mitosis (directory pharmacology summary).