سعر بينتوتيتيس 100 مجم 2022

Pentosan polysulfate sodium 100 mg hard gelatin capsules (Egypt, Andalous Pharma).

• Relief of bladder pain or discomfort associated with interstitial cystitis.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Rectal hemorrhage (6.3% at 300 mg/day in a phase 4 study), mild transaminase elevations; post-marketing pigmentary retinal changes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to the drug, structurally related compounds or excipients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Retinal pigmentary changes (pigmentary maculopathy) with long-term use; cumulative dose appears to be a risk factor.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Weak anticoagulant (1/15 of heparin activity): bleeding (rectal hemorrhage, ecchymosis, epistaxis, gum bleeding) reported; evaluate patients with bleeding risk or undergoing invasive procedures.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Anticoagulants (coumarins, heparin), t-PA, streptokinase, high-dose aspirin, NSAIDsAdditive bleeding risk with other therapies that increase bleeding risk; evaluate before use.DailyMed (U.S. National Library of Medicine)

• Animal reproduction studies did not reveal impaired fertility or fetal harm; human data not provided in the label section opened.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether excreted in human milk; use caution.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pentosan polysulfate sodium: Mechanism in interstitial cystitis unknown; adheres to the bladder wall mucosa and may buffer cell permeability against irritating urinary solutes.