سعر فيتوناديون 10مجم 5 امبول 2022

Phytonadione 10 mg 5 amp

معلومات الدواء

دواعي الاستعمالUses

Antidote to coumarin-type anticoagulants in haemorrhage or threatened haemorrhage associated with low prothrombin or factor VII.electronic medicines compendium (eMC)
Coagulation disorders due to vitamin K deficiency or interference (e.g. anticoagulant-induced hypoprothrombinaemia, hypoprothrombinaemia due to antibacterial therapy or impaired absorption).DailyMed (U.S. National Library of Medicine)

Antidote to coumarin-type anticoagulants in haemorrhage or threatened haemorrhage associated with low prothrombin or factor VII.electronic medicines compendium (eMC)
Coagulation disorders due to vitamin K deficiency or interference (e.g. anticoagulant-induced hypoprothrombinaemia, hypoprothrombinaemia due to antibacterial therapy or impaired absorption).DailyMed (U.S. National Library of Medicine)

الآثار الجانبيةSide effects

Anaphylactoid reactions after IV injection; very rarely venous irritation or phlebitis.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (eMC)

Anaphylactoid reactions after IV injection; very rarely venous irritation or phlebitis.International label, equivalent formulation · electronic medicines compendium (eMC)

موانع الاستعمالContraindications

Known hypersensitivity to any constituent.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (eMC)
Must not be given intramuscularly (depot effect complicates re-anticoagulation; haematoma risk in anticoagulated patients).نشرة دولية لتركيبة مكافئة · electronic medicines compendium (eMC)

Known hypersensitivity to any constituent.International label, equivalent formulation · electronic medicines compendium (eMC)
Must not be given intramuscularly (depot effect complicates re-anticoagulation; haematoma risk in anticoagulated patients).International label, equivalent formulation · electronic medicines compendium (eMC)

تحذيرات واحتياطاتWarnings & precautions

Boxed warning: fatal hypersensitivity reactions including anaphylaxis have occurred with IV and IM use; the US label prefers the subcutaneous route and IV injection no faster than 1 mg/minute.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
Each 1 ml ampoule contains glycocholic acid (possible bilirubin displacement); monitor INR carefully in severe liver impairment. Not an antidote to heparin.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (eMC)

Boxed warning: fatal hypersensitivity reactions including anaphylaxis have occurred with IV and IM use; the US label prefers the subcutaneous route and IV injection no faster than 1 mg/minute.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
Each 1 ml ampoule contains glycocholic acid (possible bilirubin displacement); monitor INR carefully in severe liver impairment. Not an antidote to heparin.International label, equivalent formulation · electronic medicines compendium (eMC)

التداخلات الدوائيةDrug interactions

Coumarin anticoagulants (e.g. warfarin)Vitamin K1 antagonises coumarin anticoagulants; no other significant interactions known.electronic medicines compendium (eMC)

Coumarin anticoagulants (e.g. warfarin)Vitamin K1 antagonises coumarin anticoagulants; no other significant interactions known.electronic medicines compendium (eMC)

الحمل والرضاعةPregnancy & breastfeeding

No specific safety evidence in pregnancy; use only if benefits outweigh risks. Not recommended for pregnant women as prophylaxis of vitamin K deficiency bleeding in the newborn.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (eMC)

No specific safety evidence in pregnancy; use only if benefits outweigh risks. Not recommended for pregnant women as prophylaxis of vitamin K deficiency bleeding in the newborn.International label, equivalent formulation · electronic medicines compendium (eMC)

كيف يعمل الدواءHow it works

Vitamin K is essential for hepatic formation of prothrombin and factors VII, IX and X; deficiency increases bleeding tendency (per UK SmPC S3).

Phytomenadione (vitamin K1): Vitamin K is essential for hepatic formation of prothrombin and factors VII, IX and X; deficiency increases bleeding tendency (per UK SmPC S3).

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