سعر ريكان 4مجم 20 قرص 2022

Tizanidine 4 mg tablets, pack of 20 (International Trading Office, Egypt); centrally acting alpha-2 adrenergic agonist muscle relaxant.

• Management of spasticity.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>10% and more than placebo): dry mouth, somnolence, asthenia and dizziness.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use with strong CYP1A2 inhibitors such as fluvoxamine or ciprofloxacin.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• History of hypersensitivity to tizanidine or the ingredients (including anaphylaxis and angioedema).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypotension and syncope may occur, especially with antihypertensives or on standing; do not use with other alpha-2 agonists.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Risk of liver injury: monitor aminotransferases and discontinue if liver injury occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Sedation, additive with alcohol and other CNS depressants; hallucinations/psychotic-like symptoms may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP1A2 inhibitors (fluvoxamine, ciprofloxacin)Contraindicated: markedly increased tizanidine exposure with significant hypotension, drowsiness and psychomotor impairment.DailyMed (U.S. National Library of Medicine)
• Moderate/weak CYP1A2 inhibitors (zileuton, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine)Avoid; if necessary and hypotension, bradycardia or excessive drowsiness occur, reduce dose or discontinue.DailyMed (U.S. National Library of Medicine)
• Oral contraceptivesConcomitant use not recommended; if necessary, start with lower doses.DailyMed (U.S. National Library of Medicine)

• No adequate human data; animal studies showed embryofetal and postnatal offspring mortality and growth deficits at doses below clinical exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; present in milk of lactating animals. Weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Tizanidine: Central alpha-2 adrenergic agonist that presumably reduces spasticity by increasing presynaptic inhibition of motor neurons.