سعر ابسيدين اس ار 6 مجم 10 كبسولات 2022

Tizanidine 6 mg sustained-release capsules, 10 capsules (EPCI Epcidin S.R.).

• Directory: analgesic, muscle relaxant and anti-inflammatory.
• Tizanidine (US immediate-release label): treatment of spasticity in adults.Population: AdultsDailyMed (U.S. NLM)

• Most common (>10%): dry mouth, somnolence, asthenia, dizziness.General active-ingredient information · DailyMed (U.S. NLM)

• Concomitant use of strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin); hypersensitivity to tizanidine or ingredients.General active-ingredient information · DailyMed (U.S. NLM)

• Hypotension (especially with antihypertensives; avoid other alpha-2 agonists); liver injury (monitor ALT); sedation, additive with alcohol and CNS depressants; hallucinations; hypersensitivity; withdrawal reactions on abrupt stop.General active-ingredient information · DailyMed (U.S. NLM)

• Strong CYP1A2 inhibitors (fluvoxamine, ciprofloxacin)Contraindicated: marked increase in tizanidine exposure with hypotension and sedation.DailyMed (U.S. NLM)
• Moderate or weak CYP1A2 inhibitorsAvoid; may cause hypotension, bradycardia or excessive drowsiness.DailyMed (U.S. NLM)
• Alcohol and other CNS depressantsAdditive sedation.DailyMed (U.S. NLM)

• No adequate human data; animal studies showed developmental toxicity (embryofetal and offspring mortality, growth deficits) at doses below clinical exposure.General active-ingredient information · DailyMed (U.S. NLM)
• No data on presence in human milk; present in animal milk. Weigh breastfeeding benefits against maternal need.General active-ingredient information · DailyMed (U.S. NLM)

• Tizanidine: Central alpha-2 adrenergic agonist that presumably reduces spasticity by increasing presynaptic inhibition of motor neurons.