سعر اس.ام.ار 2مجم 20 قرص 2025

• Treatment of spasticity in adults.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>10%): dry mouth, somnolence/sedation, asthenia and dizziness.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use of strong CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• History of hypersensitivity to tizanidine or tablet ingredients (anaphylaxis, angioedema).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypotension (including syncope), especially with antihypertensives or CYP1A2 inhibitors; do not use with other alpha-2 agonists.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hepatocellular liver injury may occur; monitor aminotransferases and discontinue if liver injury occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Sedation, additive with alcohol and other CNS depressants; withdrawal reactions (rebound hypertension, tachycardia, hypertonia) after abrupt stopping.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP1A2 inhibitors (fluvoxamine, ciprofloxacin)Contraindicated: markedly increased tizanidine exposure with significant hypotension and sedation.DailyMed (U.S. National Library of Medicine)
• Moderate or weak CYP1A2 inhibitors (e.g. zileuton, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, oral contraceptives, acyclovir, ticlopidine)Avoid; may cause hypotension, bradycardia or excessive drowsiness. If needed, reduce tizanidine dose or discontinue if adverse reactions occur.DailyMed (U.S. National Library of Medicine)
• Alcohol and CNS depressantsAdditive sedative effects.DailyMed (U.S. National Library of Medicine)

• No adequate human data; based on animal data (embryofetal and postnatal mortality, growth deficits) tizanidine may cause fetal harm.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk or effects on the breastfed infant; present in milk of lactating animals. Weigh breastfeeding benefits against maternal need and infant risk.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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