سعر سابريل 500 مجم اقراص 2026

Vigabatrin 500 mg oral tablets (Sabril, Sanofi) listed in Egyptian directories as an illegal (unregistered) import; antiepileptic for refractory complex partial seizures and infantile spasms.

• Adjunctive therapy of refractory complex partial seizures in patients 2 years and older with inadequate response to several alternatives (not first line)Population: Adults and children 2 years and olderDailyMed (U.S. National Library of Medicine)
• Monotherapy of infantile spasms (1 month to 2 years) when benefit outweighs risk of vision lossPopulation: Infants 1 month to 2 yearsDailyMed (U.S. National Library of Medicine)

• Most common (>=5%) with other AEDs: headache, somnolence, fatigue, dizziness, convulsion, nasopharyngitis, weight gain, visual field defect, depression, tremor, nystagmus, nausea, diarrhoea, memory impairment, insomnia, irritability, blurred vision, diplopia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• The US label lists no contraindications.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: permanent bilateral concentric visual field constriction (and possible central retinal damage); risk increases with dose and cumulative exposure, with no risk-free dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Antiepileptic drugs including vigabatrin increase the risk of suicidal thoughts and behaviour.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Withdraw gradually to avoid withdrawal seizures; somnolence and fatigue (avoid driving until effects are known); anaemia reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• PhenytoinVigabatrin may moderately reduce total phenytoin plasma levels; consider phenytoin dose adjustment if clinically indicated.DailyMed (U.S. National Library of Medicine)
• ClonazepamVigabatrin may moderately increase clonazepam Cmax, increasing clonazepam-associated adverse reactions.DailyMed (U.S. National Library of Medicine)

• No adequate human data; limited data have not established a drug-associated risk of major birth defects, but animal studies showed developmental toxicity including malformations and neurotoxicity at clinically relevant doses; pregnancy registry (NAAED) available.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Vigabatrin is excreted in human milk; breastfeeding is not recommended because of potential serious adverse reactions in the infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Vigabatrin: Believed to act as an irreversible inhibitor of GABA transaminase, the enzyme that metabolises GABA, increasing GABA levels in the central nervous system (US Sabril label 12.1).