سعر مينتافيرز 250مجم/5مل شراب 100مل 2022

Valproic acid 250 mg/5 ml oral syrup, 100 ml bottle, by Sigma (Egypt).

• Monotherapy and adjunctive therapy of complex partial seizures; sole and adjunctive therapy of simple and complex absence seizures; adjunctive therapy in multiple seizure types that include absence seizures.Population: Adults and children (complex partial seizures from 10 years)DailyMed (U.S. National Library of Medicine)

• Hepatic disease or significant hepatic dysfunction; mitochondrial disorders caused by POLG mutations (and suspected POLG disorders in children under 2); known hypersensitivity; urea cycle disorders; for migraine prophylaxis, pregnant women and women of childbearing potential not using effective contraception.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: hepatotoxicity including fatalities (usually in the first 6 months; higher risk under 2 years and with mitochondrial disorders) - test liver function before and frequently during therapy; fetal risk (neural tube defects, other major malformations, decreased IQ); pancreatitis including fatal haemorrhagic cases.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Should not be used in women who are pregnant or planning pregnancy unless other medications have failed or are unacceptable; women of childbearing potential need effective contraception and counselling.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Other risks: hyperammonaemia and hyperammonaemic encephalopathy (measure ammonia if lethargy, vomiting or mental status changes; risk with topiramate), hypothermia, thrombocytopenia (dose-related), DRESS/multiorgan hypersensitivity, suicidal behaviour and ideation, and somnolence in the elderly.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Carbapenem antibiotics (ertapenem, imipenem, meropenem)May reduce serum valproate to subtherapeutic levels with loss of seizure control; monitor levels and consider alternatives.DailyMed (U.S. National Library of Medicine)
• Aspirin; estrogen-containing hormonal contraceptivesMonitoring of valproate concentrations is recommended.DailyMed (U.S. National Library of Medicine)
• TopiramateConcomitant use is associated with hyperammonaemia with or without encephalopathy, and hypothermia.DailyMed (U.S. National Library of Medicine)

• Valproate can cause major congenital malformations (especially neural tube defects), decreased IQ and neurodevelopmental disorders; contraindicated for migraine prophylaxis in pregnancy. A pregnancy registry (NAAED) exists.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Valproate is excreted in human milk (about 1-10% of maternal serum levels); monitor the breastfed infant for signs of liver damage (jaundice, unusual bruising or bleeding).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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