سعر سيروكويل اكس ار 200مجم 10 اقراص 2022

Seroquel XR 200 mg extended-release tablets (10): quetiapine 200 mg extended-release tablets (pack of 10), the AstraZeneca originator atypical antipsychotic marketed in Egypt.

• SchizophreniaPopulation: Adults and adolescents 13-17 yearsDailyMed (U.S. National Library of Medicine)
• Bipolar I disorder, manic or mixed episodesPopulation: Adults; children and adolescents 10-17 years (monotherapy, manic episodes)DailyMed (U.S. National Library of Medicine)
• Bipolar disorder, depressive episodesPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common in adults (>=5% and twice placebo): somnolence, dry mouth, constipation, dizziness, increased appetite, dyspepsia, weight gain, fatigue, dysarthria, nasal congestion.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Most common in children and adolescents: somnolence, dizziness, fatigue, increased appetite, nausea, vomiting, dry mouth, tachycardia, weight increased.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to quetiapine or any excipient; anaphylactic reactions have been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: increased mortality in elderly patients with dementia-related psychosis; not approved for dementia-related psychosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: suicidal thoughts and behaviours; antidepressants increased this risk in children, adolescents and young adults; monitor for clinical worsening and emergent suicidality.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Cerebrovascular adverse reactions (stroke, TIA) in elderly patients with dementia; neuroleptic malignant syndrome (stop immediately); tardive dyskinesia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, indinavir, ritonavir, nefazodone)Reduce quetiapine dose to one-sixth; increase 6-fold when the inhibitor is stopped.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A4 inducers (e.g. phenytoin, carbamazepine, rifampin, St John's wort)Increase quetiapine dose up to 5-fold with chronic (>7-14 days) inducer treatment; return to the original dose within 7-14 days after stopping the inducer.DailyMed (U.S. National Library of Medicine)
• Drugs that prolong the QT intervalAvoid combination with other QTc-prolonging drugs.DailyMed (U.S. National Library of Medicine)

• Published epidemiologic data have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; consider the risks of untreated maternal illness. A US pregnancy exposure registry for atypical antipsychotics exists.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Quetiapine is present in breast milk at a relative infant dose below 1% of the maternal weight-adjusted dose; no consistent adverse effects in breastfed infants; effects on milk production unknown; weigh benefits and risks.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Quetiapine: Mechanism unknown; efficacy in schizophrenia and bipolar disorder may be mediated through combined dopamine D2 and serotonin 5-HT2A receptor antagonism (US label).