سعر سيستا 10مجم 14 كبسولة 2023

Siesta 10 mg capsules (zaleplon) by Sigma / Andalous Pharma (Egypt), a non-benzodiazepine sedative-hypnotic for short-term treatment of insomnia.

• Short-term treatment of insomnia (shown to decrease time to sleep onset for up to 30 days).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Commonly reported: headache, somnolence, dizziness, amnesia, nausea, abdominal pain, asthenia, eye pain, dysmenorrhoea, paraesthesia (see US label tables).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Patients who have experienced complex sleep behaviours after taking zaleplon.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to zaleplon or any excipient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: complex sleep behaviours (sleep-walking, sleep-driving, other activities while not fully awake) may occur and can cause serious injury or death; discontinue immediately if they occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• CNS-depressant effects and next-day impairment; take only at bedtime; caution with alcohol and other CNS depressants.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Failure of insomnia to remit after 7-10 days may indicate a primary psychiatric or medical illness; abuse, dependence and withdrawal potential (Schedule IV).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ethanol and other CNS-active drugs (e.g. imipramine)Additive CNS/psychomotor impairment.DailyMed (U.S. National Library of Medicine)
• Rifampin (CYP3A4 inducer)Markedly reduces zaleplon exposure.DailyMed (U.S. National Library of Medicine)
• CimetidineIncreases zaleplon Cmax and AUC; use 5 mg starting dose.DailyMed (U.S. National Library of Medicine)

• No adequate and well-controlled studies in pregnant women; no teratogenicity in rats and rabbits, but reduced pre-/postnatal growth and increased stillbirth/postnatal mortality in rats at maternally toxic doses; not recommended during pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• A small amount is excreted in breast milk (peak about 1 hour after the dose); nursing mothers are advised not to take zaleplon.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Zaleplon: Interacts with the GABA-A/benzodiazepine receptor complex, binding selectively to the omega-1 (alpha-1-containing) site (US label).