سعر Silvirburn 1% cream 30 gm 2024

Silvirburn silver sulfadiazine 1% cream (30 g) by Medical Union Pharmaceuticals (MUP), Egypt, for topical use on burns.

• Adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.DailyMed (U.S. National Library of Medicine)

• Transient leukopenia (mainly decreased neutrophils, maximal within 2 to 4 days of starting therapy, with recovery not influenced by continuing therapy) has been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Infrequent: skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes and interstitial nephritis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to silver sulfadiazine or any other ingredient of the preparation.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Pregnant women approaching or at term, premature infants and newborns during the first 2 months of life (sulfonamides increase the risk of kernicterus).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Absorption varies with the burned body-surface area and tissue damage; any sulfonamide adverse reaction may occur, including blood dyscrasias, serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis), hepatitis and toxic nephrosis; cross-sensitivity with other sulfonamides is possible.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Fungal proliferation in and below the eschar may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Use in some patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may be hazardous because hemolysis may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CimetidineAn increased incidence of leukopenia has been reported with concurrent cimetidine.DailyMed (U.S. National Library of Medicine)
• Topical proteolytic enzymesSilver may inactivate topical proteolytic enzymes used at the same time.DailyMed (U.S. National Library of Medicine)

• A rabbit reproduction study showed no fetal harm, but there are no adequate and well-controlled studies in pregnant women; use in pregnancy only if clearly justified.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether excreted in human milk; sulfonamides are excreted in milk and may increase the risk of kernicterus, so decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Silver sulfadiazine: Bactericidal for many Gram-negative and Gram-positive bacteria and active against yeast; acts on the bacterial cell membrane and cell wall (US Silvadene label).