سعر سلو زيم 180مجم 10 كبسول 2022

Slow-zem capsules containing diltiazem 180 mg (Pharopharma, Egypt), a non-dihydropyridine calcium channel blocker.

• Hypertension (alone or with other antihypertensives).DailyMed (U.S. National Library of Medicine)
• Chronic stable angina and angina due to coronary artery spasm.DailyMed (U.S. National Library of Medicine)

• Most common in placebo-controlled trials: headache, dizziness, bradycardia, first-degree AV block, oedema and asthenia.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Sick sinus syndrome or second-/third-degree AV block (unless a functioning ventricular pacemaker is present); hypotension (systolic <90 mmHg); hypersensitivity to diltiazem; acute myocardial infarction with radiographically documented pulmonary congestion.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Prolongs AV-node refractory period: bradycardia and second-/third-degree AV block may occur, with additive effects when combined with beta-blockers or digitalis.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Use with caution in impaired ventricular function/heart failure and watch for symptomatic hypotension.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Transaminase elevations and, rarely, acute hepatic injury (usually within 1-8 weeks, reversible on stopping); use cautiously in hepatic or renal impairment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Beta-blockers, digitalisAdditive prolongation of AV conduction; titrate slowly.DailyMed (U.S. National Library of Medicine)
• CYP3A4 and P-gp substrates, inhibitors or inducersDiltiazem is a substrate and inhibitor of CYP3A4 and P-gp; exposure of diltiazem or of co-administered drugs may change.DailyMed (U.S. National Library of Medicine)

• No well-controlled studies in pregnant women; embryo-fetal lethality and skeletal abnormalities in animals at 5-10 times the human dose. Use only if the potential benefit justifies the potential fetal risk.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Diltiazem is excreted in human milk (concentrations may approximate serum levels); if use is essential, an alternative method of infant feeding should be used.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Diltiazem: Inhibits calcium influx through slow channels in cardiac and vascular smooth muscle, dilating coronary and peripheral arteries and slowing AV-nodal conduction.